Thiothixene use while Breastfeeding
Drugs containing Thiothixene: Navane
Medically reviewed by Drugs.com. Last updated on Jan 24, 2019.
Thiothixene Levels and Effects while Breastfeeding
Summary of Use during Lactation
Because there is no published experience with thiothixene during breastfeeding, other antipsychotic agents are preferred.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Thiothixene has caused galactorrhea. Hyperprolactinemia appears to be the cause of the galactorrhea. The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Kahn JL. More on galactorrhea associated with molindone. Am J Psychiatry. 1979;136:1617-8. Letter. PMID: 574364
2. Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972;130:349-54. PMID: 4560178
3. Turkington RW. Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol Metab. 1972;34:62-6. PMID: 5061776
4. Meltzer HY, Fang VS. The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry. 1976;33:279-86. PMID: 1259521
5. Maguire GA. Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry. 2002;63(suppl 4):56-62. PMID: 11913677
CAS Registry Number
LactMed Record Number
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More about thiothixene
- Side Effects
- During Pregnancy
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- 5 Reviews
- Drug class: thioxanthenes
- FDA Alerts (2)
Other brands: Navane