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Generic Name: dupilumab (doo PIL us mab)
Brand Name: Dupixent

Medically reviewed by on Mar 7, 2018 – Written by Cerner Multum

What is dupilumab?

See also: Dupixent

Dupilumab is used in adults to treat moderate-to-severe eczema that cannot be controlled with topical medicines (for use on the skin).

Dupilumab is also used together with other medications to prevent severe asthma attacks in adults and children who are at least 12 years old.

Dupilumab may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use dupilumab if you are allergic to it.

Tell your doctor if you have ever had:

  • eye problems;

  • a parasite infection (such as roundworms or tapeworms); or

  • if you are scheduled to receive any vaccine.

Tell your doctor if you are pregnant or breast-feeding.

How should I use dupilumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Dupilumab is injected under the skin, usually once every other week. Your first dose may be given in 2 injections.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not shake the prefilled syringe. Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store prefilled syringes in their original carton in the refrigerator. Protect from light and do not freeze.

Take a syringe out of the refrigerator and let it reach room temperature for 45 minutes before injecting your dose. Leave the needle cap on the syringe until you are ready to inject your dose.

You may store a prefilled syringe at cool room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Dupilumab is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

If you also use asthma medication or any type of steroid, do not stop using it without your doctor's advice.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 7 days late for the injection. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using dupilumab?

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dupilumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching; fever, swollen glands, joint pain; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or worsening eye pain or discomfort;

  • vision changes;

  • watery eyes (your eyes may be more sensitive to light);

  • feeling like something is in your eye; or

  • blood vessel inflammation--fever, chest pain, trouble breathing, skin rash, numbness or prickly feeling in your arms or legs.

Common side effects may include:

  • pain, swelling, burning, or irritation where an injection was given;

  • eye redness or itching;

  • puffy eyelids; or

  • cold sores or fever blisters on your lips or in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dupilumab dosing information

Usual Adult Dose for Dermatitis:

Initial dose: 600 mg subcutaneously (two 300 mg injections) initially
Maintenance dose: 300 mg subcutaneously every other week

-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used, but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, it should be administered within 7 days from the missed dose and then resume the original schedule. If the missed dose is not administered within 7 days, it should be skipped until the next dose on the original schedule.

Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

What other drugs will affect dupilumab?

Other drugs may affect dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.