Skip to Content

Dupilumab

Generic Name: dupilumab (doo PIL us mab)
Brand Name: Dupixent

Medically reviewed by Drugs.com on Jul 5, 2019 – Written by Cerner Multum

What is dupilumab?

Dupilumab is used to treat moderate-to-severe eczema (atopic dermatitis) that cannot be controlled with topical medicines (for use on the skin).

Dupilumab is also used together with other medications to treat moderate-to-severe asthma that is not controlled with other asthma medicines.

Dupilumab is used for asthma or eczema in adults and children at least 12 years old.

Dupilumab is used only in adults to treat a condition called chronic rhinosinusitis (long-term sinus inflammation) that is associated with nasal polyps.

Dupilumab may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use dupilumab if you are allergic to it.

Dupilumab should not be given to a child younger than 12 years old.

Tell your doctor if you have ever had:

  • eye problems;

  • a parasite infection (such as roundworms or tapeworms); or

  • if you are scheduled to receive any vaccine.

Tell your doctor if you are pregnant or breastfeeding.

How should I use dupilumab?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Dupilumab is injected under the skin, usually once every other week. Your first dose may be given in 2 injections.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not shake the prefilled syringe. Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store prefilled syringes in their original carton in the refrigerator. Protect from light and do not freeze.

Take a syringe out of the refrigerator and let it reach room temperature for 45 minutes before injecting your dose. Leave the needle cap on the syringe until you are ready to inject your dose.

You may store a prefilled syringe at cool room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Dupilumab is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

If you also use a steroid medication, your dose needs may change while using dupilumab. Do not change your steroid dose or dosing schedule without your doctor's advice.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 7 days late for the injection. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using dupilumab?

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dupilumab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or worsening eye pain or discomfort;

  • vision changes;

  • watery eyes (your eyes may be more sensitive to light);

  • feeling like something is in your eye; or

  • blood vessel inflammation--fever, chest pain, trouble breathing, skin rash, numbness or prickly feeling in your arms or legs.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dupilumab?

Other drugs may affect dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide