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What drugs should I avoid if I have shellfish allergies?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on June 8, 2025.

Official Answer by Drugs.com

People with shellfish allergies need to be vigilant not only about the foods they eat, but also about certain medications and supplements, as some may contain ingredients derived from shellfish. Here’s a guide to help you identify which products to avoid and how to stay safe.

What is a Shellfish Allergy?

A shellfish allergy is a reaction to proteins found in crustaceans (like shrimp, crab, and lobster) and mollusks (such as clams, oysters, and scallops). The main culprit behind these allergic reactions is a protein called tropomyosin. It is a common and often life-long allergy that can cause symptoms ranging from mild hives and swelling to severe, life-threatening anaphylaxis.

What Medications Should I Avoid if I Have a Shellfish Allergy?

In addition to avoiding shellfish in food, certain medications and supplements can also pose a risk due to their ingredients. If you have a shellfish allergy, check with a healthcare professional before taking the following medications or supplements.

1. Glucosamine Supplements

Glucosamine is commonly used to manage arthritis and joint pain. Many glucosamine supplements are made from the shells of shrimp, crab, or lobster. While some research suggests that these supplements may not contain enough shellfish protein to trigger an allergic reaction in most people, the risk cannot be completely ruled out, especially if you have a severe allergy.

To be safe, opt for shellfish-free glucosamine or alternatives like chondroitin, which do not contain shellfish ingredients.

2. Chitin and Chitosan

Chitin is a natural substance found in the hard outer shells of shellfish and is sometimes used in weight loss supplements, certain fat absorbers (like chitosan), and even some moisturizers.

People with shellfish allergies are advised to avoid products containing chitin or chitosan, as these may be contaminated with shellfish proteins.

3. Calcium Supplements

Some calcium supplements are made using ground oyster shells. The risk of this type of calcium triggering an allergic reaction in people with shellfish allergies is unclear. If you have a shellfish allergy, check the ingredient list carefully or consult your doctor or pharmacist before using these products.

4. Fish Oil Supplements

Fish oil supplements, such as cod liver oil, are generally made from fish, not shellfish. However, there is a possibility of cross-contamination, and trace amounts of shellfish proteins could be present. If you are highly sensitive, you may want to avoid fish oil or choose plant-based alternatives like flaxseed oil.

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5. Prescription Medications

Shellfish-derived ingredients are rarely found in prescription medications, but always check with your healthcare provider or pharmacist about the ingredients, especially if you are starting a new medication.

Can I Take Iodine or Contrast Dyes If I Have a Shellfish Allergy?

There is a common misconception that people with shellfish allergies should avoid iodine or iodinated contrast dyes used in medical imaging. However, the allergen in shellfish is a muscle protein, not iodine. Scientific evidence shows no link between shellfish allergy and allergic reactions to iodine or contrast dyes.

Tips on How to Stay Safe

If you have a shellfish allergy, there are several things you can do to prevent an allergic reaction or severe complications if one does occur:

Summary

In conclusion, while the fear of iodine is largely unfounded for those with shellfish allergies, a few specific supplements and medication ingredients warrant caution. Some examples of medications and supplements to avoid if you have a shellfish allergy include glucosamine, certain calcium supplements, and fish oil. Open communication with your healthcare providers and diligent label-reading are your best defenses to safely manage your health while living with a shellfish allergy.

References
  1. American Academy of Allergy Asthma & Immunology. Shellfish Allergy is not a Shell Game. Accessed on June 7, 2025 at https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/shellfish-allergy-can-be-dangerous
  2. British Society for Allergy and Clinical Immunology. Shellfish & Fish Allergy. Accessed on June 7, 2025 at https://mft.nhs.uk/app/uploads/sites/7/2018/04/Shellfish_and_Fish.pdf
  3. Chu, E. C., et. al. 2023. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus, 15(3), e36310. https://doi.org/10.7759/cureus.36310
  4. Elieh-Ali-Komi, D., et. al. 2016. Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials. International journal of advanced research, 4(3), 411–427. PMID: 27819009 PMCID: PMC5094803
  5. Gray, H. C., et. al. 2004. Is glucosamine safe in patients with seafood allergy?. The Journal of allergy and clinical immunology, 114(2), 459–460. https://doi.org/10.1016/j.jaci.2004.05.050
  6. Mhurchu, C. N., et. al. 2005. Effect of chitosan on weight loss in overweight and obese individuals: a systematic review of randomized controlled trials. Obesity reviews : an official journal of the International Association for the Study of Obesity, 6(1), 35–42. https://doi.org/10.1111/j.1467-789X.2005.00158.x
  7. UC Davis Health. 2022. What you need to know about shellfish allergy diagnosis, treatment. Accessed on June 7, 2025 at https://health.ucdavis.edu/news/headlines/what-you-need-to-know-about-shellfish-allergy-diagnosis-treatment/2022/10
  8. Villacis, J., et. al. 2006. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 36(11), 1457–1461. https://doi.org/10.1111/j.1365-2222.2006.02590.x

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