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Scientific Name(s): Linum usitatissimum L.
Common Name(s): Flax, Flaxseed, Linseed, Lint bells, Linum

Medically reviewed by Last updated on Dec 19, 2022.

Clinical Overview


Flaxseed and flaxseed oil contain various essential fatty acids but are particularly rich in alpha linolenic acid (ALA). Flaxseed (but not flaxseed oil) also has a high fiber content that may have health benefits similar to those of other high-fiber products and phytoestrogens. Historically, linseed oil, derived from flaxseed, has been used as a topical demulcent and emollient, as a laxative, and as a treatment for coughs, colds, and urinary tract infections. Interest in flaxseed centers on atherosclerosis, cancer, diabetes, and to a lesser extent, menopause, attention deficit hyperactivity disorder, bipolar disorder, and systemic lupus erythematosus (SLE).


Flaxseed (whole or ground) has been used in clinical trials at doses from 5 to 50 g/day or 4 to 60 mL flaxseed oil daily, and has been used in children at doses equivalent to 400 mg of ALA in divided doses.

Eight grams of ground flaxseed (or 2.5 g of flaxseed oil) per day provides a daily intake of 1.1 g of ALA for women and 1.6 g for men.


Contraindicated in patients with known hypersensitivity to flaxseed.


The use of flaxseed and flaxseed oil during pregnancy and lactation is not recommended.


None well documented.

Adverse Reactions

Flaxseed and flaxseed oil appear to be well tolerated, with few adverse reactions reported usually related to flaxseed allergy. Flaxseed-induced anaphylaxis and flaxseed oil-induced gynecomastia have also been reported.


The US Food and Drug Administration has not granted GRAS (Generally Recognized as Safe) status to flaxseed or flaxseed oil. The safety of ingested amounts greater than 50 g/day of flaxseed is not established.

Scientific Family

  • Linaceae (flax)


The flax plant is a slender annual that grows to 0.3 to 0.9 m in height. It branches at the top and has small, pale green, alternating leaves. The dark yellow seed is oval and flat, about 5 mm long, with a hull, an endosperm, and 2 embryos. Flax was introduced to North America from Europe and now grows widely in Canada and the northwestern United States. Each branch is tipped with 1 or 2 delicate blue flowers that bloom from February through September. Additional members of the genus Linum are used throughout the world for their fiber and oil content.1, 2


Flax has probably been used for 12,000 years as a source of fiber for producing linen and was one of the earliest plants used for purposes other than food. The name usitatissimum is derived from Latin, meaning "very useful." Flax is processed from fibers in the plant's stem. Flaxseed or linseed oil, derived from the seed, has been used as a topical demulcent and emollient and as a laxative, particularly for animals. Flaxseed oil is also used in paints and varnishes, and as a waterproofing agent. Flaxseed cakes, the residue after pressing of oil, have been used as cattle feed. Traditional medicinal uses of the plant have been varied and at times unusual; one text notes use of the seed for removing foreign material from the eye. A moistened seed was placed under the closed eyelid for a few moments to allow the material to adhere to the seed, thereby facilitating removal. Other uses include the treatment of coughs and colds, constipation, and urinary tract infections. The related Linum catharticum yields a purgative decoction.2, 3, 4, 5

The German Commission E sanctions the use of flaxseed for the treatment of chronic constipation, colon damage from laxative abuse, irritable colon, and diverticulitis. It is also approved as a mucilage for gastritis and enteritis. When used externally, it is approved as a poultice for local inflammation.6


The medical properties of flax are primarily associated with the seed. Studies have attributed different medicinal properties to unsaturated fatty acids (mainly ALA and linoleic acid), lignans (predominantly secoisolarciresinol diglucoside), and nonstarch polysaccharides (ie, gum, fiber). Flax produces a seed that contains 38% to 45% oil. Also known as linseed oil, it is obtained by crushing and compressing the seeds. The oil is composed of approximately 70% polyunsaturated fatty acids, including linolenic, linoleic, and oleic acids; approximately 18% monounsaturated fatty acids; and approximately 9% saturated fatty acids. Flaxseed oil is among the best natural sources of ALA, an omega-3 fatty acid. Linoleic acid, a rich source of omega-6 fatty acid, and ALA are critical for the structural integrity of cell membranes. ALA is a precursor to the longer and more unsaturated omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid ; however, only a modest amount of ALA appears to be converted to these longer chain fatty acids in the human body.2, 4, 7, 8, 9

Whole or ground flaxseed is a rich source of lignans (often termed phytoestrogens), including secoisolariciresinol and matairesinol. These lignans are believed to exert antioxidant and phytoestrogenic effects. They are converted by bacteria in the colon to the active metabolites enterodiol and enterolactone. These metabolites are reported to have greater antioxidant activity than the parent lignan secoisolarciresinol diglucoside and also exert either weak estrogenic or antiestrogenic effect, depending on biological levels of estradiol.4, 10, 11, 12, 13, 14

Whole or ground flaxseed is a source of soluble fiber mucilage that is also found in other members of the genus Linum. This gum-like material contains polysaccharides containing D-xylose, L-rhamnose, L-galactose, arabinose, D-galacturonic and mannuronic acids, fucose, and glucuronic acid. Flaxseed may also contain phenylpropanoids (eg, p-coumaric acid, o-coumaric acid, linusitamarin), niacin, folic acid, tocopherol, potassium, and phosphorous, and provides about 28% of total dietary fiber per 100 g dry weight.2, 3

The nutrient composition of the 3 forms of flaxseed differs. Unlike whole and ground flaxseed, flaxseed oil is devoid of fiber and lignans. Flax leaves and seed chaff contain the cyanogenic glycosides (including linamarin, linustatin, and neolinustatin); however, heating appears to destroy these constituents.2, 3, 4, 8, 15, 16

Uses and Pharmacology

Antioxidant effects

The lignan secoisolarciresinol diglucoside has been shown to possess antioxidant properties.(7, 14) The clinical relevance of the effects of lignan alone or flaxseed have not been established.(14, 42, 48)

Antiplatelet effects

Secoisolarciresinol diglucoside, which is associated with anti-inflammatory activity, has been shown to act as an antagonist of platelet-activating factor.(14, 25, 26) While theoretical mechanisms of action and epidemiological data point to a potential platelet inhibitory effect of ALA, human studies have not shown a consistent antiplatelet effect.(8, 27)

Appetite suppression

Flaxseed dietary fiber may contribute to a sensation of satiety and fullness.(49)

Attention deficit hyperactivity disorder (ADHD)

ADHD is commonly associated with decreased blood omega-3 fatty acid levels.(50) A pilot study evaluated the effect of ALA-rich supplementation with flax oil and antioxidant emulsion on blood fatty acid composition and behavior in children with ADHD. Postsupplementation levels of red blood cell membrane fatty acids were higher than pretreatment and control levels. An improvement in symptoms was reflected by reduction in total hyperactivity scores of ADHD children.(51)

Bipolar disorder

Despite theoretical support and evidence suggesting that omega-3 oil is beneficial,(52) the effects of flaxseed oil supplementation did not differ from those of placebo in either bipolar depression or mania in a clinical study.(53)


Effects of flaxseed oil and olive oil compared with mineral oil were evaluated in 50 adult hemodialysis patients with constipation. Initial doses of oils were 4 mL/day and adjusted as needed over the 4-week study period; 82% of patients on flaxseed oil required adjustments (average final dose, 6.9 ± 2.7 mL/day) compared with 69% and 53% for olive and mineral oils, respectively. Rome III scores improved significantly with each of the 3 oil treatments (P < 0.01 for each). Flaxseed oil yielded improvements in the frequency and consistency of stools, whereas mineral and olive oils improved scores in 5 of the 6 total constipation symptoms. Diabetic nephropathy, hypertensive nephrosclerosis, glomerulonephritis, and polycystic kidney disease were the main etiologies that led to chronic kidney disease.(88)


Oral supplementation with flaxseed oil may improve skin hydration and reduce sensitivity.(54, 55)


Phytoestrogens and ALA have been purported to have cancer protective effects; however, the mechanism by which these compounds exert their chemoprotective effect has not been completely explained.(4, 28)

Animal data

Animal studies have been conducted on flaxseed and constituent lignans in colon cancer, melanoma, and the mammary gland with positive results. Flaxseed oil did not appear to exert a protective effect in the colon cancer study.(7, 14) Observational studies and in vitro investigations on cancer cell cultures have also been reported.(14, 29, 30)

Clinical data

Trials are lacking for the specific use of flaxseed in breast cancer,(27) and the relevance of omega-3 fatty acids or ALA in risk of breast cancer is debated.(31) In a small study in newly diagnosed postmenopausal breast cancer patients, dietary flaxseed showed positive effects on tumor markers compared with those of placebo, including a reduction in Ki-67 labeling index (a measure of the rate of tumor cell proliferation), a reduction in c-erbB2 score, and an increase in apoptosis index.(32)

Data are conflicting for prostate cancer. Previous epidemiologic evidence suggested that ALA increases the risk for prostate cancer(33, 34, 35); however, small studies have shown benefit for flaxseed.(33, 36, 37) Until unequivocal data are available, flaxseed consumption by men with prostate cancer should be under the guidance of a medical practitioner.(7)

The antioxidant properties and the antiangiogenic effects of lignans cannot be excluded as mechanisms by which flaxseed may exert its beneficial effect on prostate cancer.(33) Flaxseed lignans were effective in preventing symptoms associated with benign prostatic hyperplasia in 1 clinical study.(38)

Diabetes/Metabolic syndrome

Animal data

Animal studies have been conducted both to ascertain the effects of flaxseed on metabolic syndrome and diabetes models as well as to elucidate mechanisms of action. Soluble fiber and other components of flaxseed fractions could potentially affect insulin secretion and its mechanisms of action in maintaining plasma glucose homeostasis, possibly decreasing postprandial glucose response and improving glucose tolerance.(8, 39)

Clinical data

Improved glycemic control due to flax fiber and the lignan secoisolarciresinol diglucoside has been demonstrated in healthy volunteers,(40) postmenopausal women, and hyperlipidemic men.(41, 42, 43) The lignan secoisolarciresinol diglucoside and ground flaxseed, but not flaxseed oil,(44) reduced insulin resistance and improved glycemic control and lipid profiles in patients with type 2 diabetes,(14, 45) and in glucose-intolerant obese people.(46) In a randomized trial (n = 25), daily ground flaxseed supplementation for 12 weeks improved glucose, insulin, and insulin sensitivity in prediabetic overweight or obese men and postmenopausal women; significant results were seen with 13 g (2 tablespoonsful) but not 26 g/day.(76) A study in Chinese adults with risk factors of metabolic syndrome (n = 173) reported that flaxseed (30 g/day contained in bread) provided beneficial changes in some cardiometabolic biomarkers but overall provided no additional benefit over lifestyle counseling; the form of flaxseed used (ground or whole) is uncertain due to ambiguity throughout the text.(77) However, neither ground flaxseed nor flaxseed oil enhanced glycemic control in individuals with well-controlled type 2 diabetes in another study.(47)

Meta-analyses of datasets from 7 randomized controlled trials conducted in patients with prediabetes or type 2 diabetes demonstrated statistically significant improvements with flaxseed supplementation compared to controls in fasting blood glucose (P<0.001) and insulin concentrations (P=0.022) overall, and improvements in HbA1c (P=0.008) and insulin resistance (P=0.024) in patients with type 2 diabetes. Heterogeneity was low in all comparisons except for fasting blood glucose, which was high. Doses ranged from 13 to 40 g/day taken for 8 to 12 weeks; however, the method of supplementation varied for each study and included being added to meals, juices, yogurts, water, or baked goods.(100)

The addition of flaxseed gum to glucose solutions or liquid and gelled dairy products was associated with minimal effects on postprandial blood glucose or insulin levels in healthy males in a randomized, double-blind, crossover, postprandial study (n = 12). Although glucose area under the curve and GI values were significantly lower with flaxseed gum- (2.5 g) and soy-soluble polysaccharide-fortified (2.25 g) products than the glucose reference, the significant inverse correlation to product viscosity (which was greatest with flaxseed gum) pointed to this as the more relevant factor. Fortification of food products, especially dairy, with low-viscosity soluble fibers does not appear to be a useful means of attenuating postprandial blood glucose or insulin response.(79)

The American Diabetes Association's updated guidelines on the standards of medical care in diabetes (2021) recommends individualized medical nutrition therapy program as needed to achieve treatment goals for all people with type 1 or 2 diabetes, prediabetes, and gestational diabetes (level A), with dietary fats supplied by eating foods rich in long-chain omega-3 fatty acids, including seeds containing alpha-linolenic acid, to prevent or treat cardiovascular disease (level B).(84)


Animal studies

Numerous animal studies have been conducted, demonstrating reduced atherosclerotic lesions, decreased platelet aggregation, decreased total and low-density lipoprotein - cholesterol (LDL-C), and prolongation of the QT interval. Studies investigating the role of flaxseed in stroke prevention in animals are lacking.(7, 14, 17, 18) However, the availability of clinical trial and epidemiological data makes evidence from animal studies less relevant.

Clinical studies

Multiple studies have been conducted among healthy volunteers but may be of questionable relevance; baseline lipid levels and comorbidity may affect measured outcomes. Clinical data are also often limited to measuring secondary end points, with epidemiological data on ALA in general, and not flaxseed in particular, providing a basis for recommendations for use of flaxseed in preventing primary end points such as myocardial infarction, stroke, or death from atherosclerotic disease.(17)

Reviews of the effect of flaxseed on serum cholesterol(7, 8, 14, 17, 19) and a meta-analysis(18) have been published. Studies are heterogeneous in participant inclusion, dosage regimens, and flaxseed products used.(14)

A meta-analysis of 28 clinical trials up to 2008 found that whole flaxseed and lignan alone (but not flaxseed oil) modestly reduced total cholesterol by −0.10 mmol/L (−3.9 mg/dL) (95% confidence interval [95% CI], −0.2 to 0 mmol/L [−7.7 to 0 mg/dL]) and LDL-C by 0.08 mmol/L (−3.1 mg/dL) (95% CI, −0.16 to 0 mmol/L [−6.2 to 0 mg/dL]). No changes in high-density lipoprotein - cholesterol (HDL-C) or triglycerides were found. Gender and initial lipid profiles influenced efficacy.(18)

Clinical studies published after the meta-analysis in patients with metabolic syndrome or elevated cholesterol have produced similar findings on LDL levels.(20, 21, 22, 23) No effect on markers of inflammation was found in these or other studies.(19, 20, 21, 24, 80) However, a cross-sectional and follow-up dietary intervention study in hemodialysis patients (n = 30) documented significantly improved blood pressure, total cholesterol, triglyceride/HDL-C ratio, serum triglycerides, glucose tolerance, serum fatty acid composition, and inflammatory markers (ie, interleukin [IL]-6, tumor necrosis factor [TNF]-alpha, high-sensitivity C-reactive protein [hs-CRP]) after 12 weeks of dietary supplementation with 30 g/day of a milled flax-sesame-pumpkin seed (3:1:1) mixture added to 200 mL of fat-free milk before dinner. Pruritis also improved in all patients.(85) A smaller double-blind, randomized, controlled study in 38 hemodialysis patients observed a significant reduction from baseline (P<0.05) and controls (P<0.01) only in serum triglycerides (−42 mg/dL) after 8 weeks of 6 g/day flaxseed oil. Total cholesterol, LDL, HDLC, and lipoprotein(a) were not significantly affected in either group.(93) A double-blind, randomized, placebo-controlled trial from 2015 studied the effect of flaxseed in 110 patients with peripheral artery disease, of which 74% were on concomitant cholesterol lowering medication (mostly statins). A significant reduction (8.5%) in LDL cholesterol was observed compared with baseline in patients taking antihyperlipidemics plus supplemental foods containing 30 g of milled flaxseed over a 12-month period. Milled flaxseed lowered total and LDL cholesterol compared to placebo when used in combination with cholesterol-lowering medication. In contrast, no differences were found between flax and control groups despite changes over time in percent and rate of platelet aggregation.(87) A nonblind, randomized, controlled trial reported significant benefit in weight, body mass index (BMI), and lipid values in hyperlipidemic Iranian adults who supplemented their diet with 30 g/day of flaxseed for 40 days. Mean differences within the flaxseed and control groups in total cholesterol, LDL-C, and triglylcerides were −11.5 and +16.4, −3.1 and +9.5, and −49.5 and +17.7, respectively; HDL-C was not significantly affected. A mean reduction in weight of 1 kg and in BMI of 0.5 was also reported as significant.(90) A study in healthy adults found statistically significant reductions in total (−5%) and LDL-C (−6.7%) levels.(80) A pediatric study in patients with elevated LDL-C levels found no significant reduction in total or LDL-C levels, but HDL-C levels were significantly reduced (−15%), and triglyceride levels were significantly elevated (26%).(81)

The effects of ALA on cardiovascular risk factors, including small dense LDL-C, were evaluated in a randomized, double-blind, crossover study in 15 healthy Japanese men. Flaxseed oil 10 g (ALA 5.49 g/day) or corn oil (ALA 0.9 g/day) were administered for 12 weeks, each separated by an 8-week washout period. ALA levels were significantly higher while linoleic acid and alpha-tocopherol were significantly lower during flaxseed administration compared with corn oil. Additionally, eicosapentaenoic acid (EPA) was significantly higher during the flaxseed oil period and the ratio of omega-6 to omega-3 fatty acid levels was significantly lower. Lipid parameters were significantly improved with supplementation of flaxseed oil compared to corn oil, including total cholesterol, LDL, HDL, non-HDL, apolipoprotein A1 and B, as well as cholesterol ester transfer protein activity. Small dense LDL concentrations were significantly lower with flaxseed oil at 4 weeks but not at 12 weeks. No symptoms or side effects of the test diets were reported by subjects.(89)


The American College of Rheumatology guidelines on the management of gout (2012) suggested that the use of various oral complementary agents, including flax, was inappropriate for the treatment of an acute attack of gout.(74)


A randomized, double-blind, placebo-controlled trial enrolling 110 adults with peripheral artery disease evaluated the effects of milled flaxseed (30 g/day provided in a variety of food products) on blood pressure. After 6 months, systolic (SBP) and diastolic blood pressure (DBP) were significantly lower in the flax group (approximately 10 mm Hg and 7 mm Hg reductions, respectively); greater improvement (15 mm Hg reduction in SBP) was noted in hypertensive patients with SBP 140 mm Hg or higher at baseline. The effect was maintained at a 1-year follow up and was demonstrated in the presence of antihypertensive medications, indicating an effective nonpharmacological addition to current pharmacological regimens.(78) The mechanism of action of blood pressure reduction with flaxseed was assessed in a follow-up study using the plasma of the participants in the FlaxPAD study. Although blood pressure was inversely associated with alpha-linolenic acid (ALA), the mechanism of action was still unclear. Oxylipins, polyunsaturated fats that regulate vascular tone, were evaluated from 76 participants. Of the 9 plasma oxylipins that had significantly different changes from baseline between flaxseed and control groups, 6 were significantly lower than controls (P < 0.05) and were products of soluble epoxide hydrolase. A strong inverse association was seen between ALA and percent of initial activity of soluble epoxide hydrolase (P = 0.0048), a pharmacological target for treatment.(83)

A meta-analysis of randomized, controlled trials (11 studies, N = 1,004) published until July 2014 that studied flaxseed (whole, ground, or extracts) in adults identified a significant reduction in the mean difference in systolic blood pressure by −1.77 mm Hg (P = 0.04) and diastolic blood pressure by −1.16 mm Hg (P < 0.003) with no heterogeneity. Whole or ground seed provided greater reduction in systolic blood pressure when compared to oil or lignin. Subgroup analysis revealed parallel study designs to be a factor for showing significant reductions in blood pressure. Additionally, supplement duration longer than 12 weeks, consumption of whole flaxseed, and a baseline blood pressure less than 130 mm Hg to each be factors for reporting significant reductions in diastolic blood pressure. Doses varied from 30 to 50 g/day for whole flaxseed, 1.2 to 28 g/day of oil, and 360 to 600 mg /day of lignin. Mild cases of constipation and other GI complaints were reported in 2 studies; no major side effects were noted.(86)

Lupus nephritis

Glomerulonephritis is a common and serious complication of SLE, and flaxseed has shown potential in helping patients who develop lupus nephritis.(56) Preliminary evidence derived from a mouse model of lupus indicates that diets supplemented with 15% flaxseed for 14 weeks delayed the onset of proteinuria and reduced overall mortality compared with controls.(26) Flaxseed contains high levels of the lignan precursor secoisolarciresinol diglucoside, which is associated with anti-inflammatory activity (eg, formation of less inflammatory classes of renal prostanoids), thus offering a renoprotective effect. Nine patients with SLE taking part in a single-blind, randomized clinical trial who received flaxseed 30 g/day and prednisone for 1 year, followed by crossover to a year without flaxseed supplementation, experienced improvements in renal function.(58)

Menopausal symptoms

The photoestrogenic content of flaxseed may benefit women suffering from menopausal symptoms.(59) Clinical studies, however, are equivocal in their results for either flaxseed or lignans alone in reducing menopausal symptoms (hot flashes).(41, 59, 60, 61, 62) Doses of up to 410 mg lignan were not more effective than placebo in reducing hot flashes in a study of 188 women.(61) The Society of Obstetricians and Gynaecologists of Canada revised clinical practice guidelines on managing menopausal vasomotor symptoms (2021) do not recommend flaxseed based on a lack of evidence to support clinical benefit.(99) Likewise, the Endocrine Society clinical practice guidelines for the treatment of symptoms of menopause (2015) recommend counseling patients on the lack of consistent evidence for benefit of complementary medicine therapies, including flaxseed, as an alternative nonhormonal therapy for vasomotor symptoms (weak recommendation; low quality evidence).(92) The North American Menopause Society position statement for nonhormonal management of menopause-associated vasomotor symptoms (2015) states that accumulated evidence at the time of publication does not support use of flaxseed for vasomotor symptoms (Level I).(97)

Vegetarian diet

Clinical diet

The Academy of Nutrition and Dietetics' updated position paper on vegetarian diets (2016) states that adequate nutrition can be provided by a well-planned vegetarian diet that includes seeds. Therapeutic vegetarian diets are useful in maintaining a healthy weight and BMI and are associated with a reduction in cardiovascular disease risk and type 2 diabetes. Flax seeds and their oil are one of the most concentrated plant sources of omega-3 fatty acids, and seeds, in general, are a source of protein and zinc.(91)


The US Food and Drug Administration has not granted GRAS status to flaxseed or flaxseed oil, although the agency does allow up to 12% flaxseed in food by weight.7 However, based on available data, it appears that flaxseed and its oil are safe in doses of up to 50 g/day.2, 3, 7, 86

Flaxseed oil is rich in ALA and is suitable for purposes attributed to the fatty acid; however, it does not contain fiber or lignans.3

Eight grams of ground flaxseed or 2.5 g of flaxseed oil per day provide the Institute of Medicine’s daily adequate intake of 1.1 g of ALA for women and 1.6 g for men.3

Flaxseed (whole or ground) has been used in clinical trials at doses from 5 to 50 g/day or 60 mL flaxseed oil daily,3 and has been used in children (combined with vitamin C 25 mg) at doses equivalent to 400 mg of ALA in divided doses.51 Twenty-five grams of unground seed did not appear to be adequate as a therapeutic dose to induce changes in plasma lipids and several biomarkers of oxidative stress in a small study.63 A meta-analysis investigating the effect of flaxseed consumption on blood pressure summarized the daily dose of flaxseed from 11 studies as follows: 30 to 50 g/day (whole flaxseed), 1.2 to 28 g/day (flaxseed oil), and 360 to 600 mg/day (flaxseed lignan).86

Pregnancy / Lactation

The use of flaxseed and flaxseed oil during pregnancy and lactation is not recommended. Animal studies show possible harmful effects,64, 65 and human data are insufficient.66 Flaxseed may increase serum luteinizing hormone or testosterone and could be detrimental in pregnancy.7, 14, 67, 68 Flaxseed oil may increase the risk of premature birth if consumed during the second and third trimesters.82


Flaxseed, but not flaxseed oil, contains mucilage; thus, absorption of coadministered drugs may be affected.7 Oral drugs should be taken 1 hour before or 2 hours after flaxseed to prevent decreased absorption.7

Theoretically, flaxseed and flaxseed oil may potentiate the effects of anticoagulants, antiplatelet agents, nonsteroidal anti-inflammatory drugs, antihyperlipidemic agents, antihypertensive agents, and mood stabilizer agents; however, no clinical cases have been reported.7 Flaxseed, but not flaxseed oil, by virtue of its fiber content may increase or enhance the effects of laxatives.69 Because of its phytoestrogen content, it may exhibit weak estrogenic or antiestrogenic effects and has the potential to interact with oral contraceptives or hormone-replacement therapy.7 Linatine inhibits the absorption of pyridoxine (vitamin B6), and phytic acid reduces calcium, copper, iron, magnesium, and zinc absorption.2, 3 At dosages of 45 g flaxseed daily, no change in serum pyridoxine was observed after 5 weeks, and there is no evidence that mineral absorption is clinically affected.3

Ibrutinib: Flaxseed oil may enhance the antiplatelet effect of ibrutinib. Monitor therapy. The ibrutinib Canadian product monograph recommends avoiding this combination.95, 96

Adverse Reactions

Flaxseed and flaxseed oil appear to be well tolerated, with few adverse reactions reported.(7) Many of the reported reactions have been associated with allergy to flaxseed(7) and include palmar pruritus, generalized urticaria, nausea/vomiting, intestinal/abdominal pain, diarrhea, sneezing, nasal obstruction, and intense general malaise.(7, 70, 71) Rarely, anaphylaxis, including facial angioedema, oral pruritus, dyspnea, urticarial, and persistent abdominal cramps, has been reported.(75, 94) Because type 1 hypersensitivity to flaxseed oil has been confirmed, it is contraindicated in patients with known hypersensitivity.(7, 70, 71) Approximately 50% of workers exposed to flax demonstrated immunologically positive antigen tests in 1 survey.(72)

Flaxseed, but not flaxseed oil, can cause digestive symptoms similar to those of other dietary fibers, including bloating, flatulence, abdominal pain, diarrhea, dyspepsia, and nausea.(59) Anecdotally, intestinal obstruction may occur from mass effect when large amounts of flaxseed, but not flaxseed oil, are ingested or taken with an inadequate amount of water.(7)

A case of gynecomastia in a 70-year-old man has been reported subsequent to daily consumption of flaxseed oil. Breast pain and swelling were reported approximately 3 months after taking 1 tablespoonful of flaxseed oil daily. Symptoms ceased within 3 months of stopping the flaxseed oil supplement.(98)


The US Food and Drug Administration has not granted GRAS status to flaxseed or flaxseed oil, although the agency allows up to 12% flaxseed in food by weight.7 However, based on available data, it appears that flaxseed and its oil are safe in doses of up to 50 g/day.2, 3, 7

The cyanogenic properties of some flax constituents theoretically suggest that ingestion of large amounts of the plant may be harmful; heating, however, appears to destroy the cyanogenic glycosides.3

Anecdotally, an overdose of flaxseed or its oil may result in weakness, unstable gait, paralysis, or seizures.70 The physiologic balance between ALA and linoleic acid may be relevant, and ALA deficiency may cause neurologic abnormalities.73 Rats fed high-dose secoisolarciresinol diglucoside lignan showed no adverse effects on growth, nor hepatotoxicity.14 Flaxseed contains small, probably insignificant, amounts of cadmium (0.2 to 0.6 mg/kg).19 Immature flaxseed seedpods may be poisonous.7



This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

1. Linum usitatissimum. USDA, NRCS. 2007. The PLANTS Database (, December 11, 2012). National Plant Data Team, Greensboro, NC 27401-4901 USA.
2. Singh KK, Mridula D, Rehal J, Barnwal P. Flaxseed: A potential source of food, feed and fiber. Crit Rev Food Sci Nutr. 2011;51(3):210-222.21390942
3. Thompson LU, Cunnane SC, eds. Flaxseed in Human Nutrition. 2nd ed. Champaign, IL: AOCS Press; 2003:2525-2531.
4. Hall C III, Tulbek MC, XU Y. Flaxseed. Adv Food Nutr Res. 2006;51:1-97.
5. Evans WC. Trease and Evans' Pharmacognosy. 13th ed. London: Balliere Tindall; 1989.
6. Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine, Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000.
7. Basch E, Bent S, Collins J, et al. Flaxseed and flaxseed oil (Linum usitatissimum): A review by the Natural Standards Collaboration. J Soc Integr Oncol. 2007;5(3):92-105.17761128
8. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev. 2004;62(1):18-27.14995053
9. Kris-Etherton PM, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation. 2002;106(21):2747-2757.12438303
10. Kamal-Eldin A, Peerlkamp N, Johnsson P, et al. An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl-glutaric acid residues. Phytochemistry. 2001;58(4):587-590.11576603
11. Charlet S, Bensaddek L, Raynaud S, Gillet F, Mesnard F, Fliniaux M. An HPLC procedure for the quantification of anhydrosecoisolariciresinol. Application to the evaluation of flax lignan content. Plant Physiol Biochem. 2002;40:225-229.
12. Kitts DD, Yuan YV, Wijewickreme AN, Thompson LU. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem. 1999;202(1-2):91-100.10705999
13. Brooks JD, Ward WE, Lewis JE, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr. 2004;79(2):318-325.14749240
14. Adolphe JL, Whiting SJ, Juurlink BH, Thorpe LU, Alcorn J. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010;103(7):929-938.20003621
15. Johnsson P, Peerlkamp N, Kamal-Eldin A, et al. Polymeric fractions containing phenol glucosides in flaxseed. Food Chem. 2002;76(2):207-212.
16. Luyengi L, Pezzuto JM, Waller DP, et al. Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum. J Nat Prod. 1993;56(11):2012-2015.8289068
17. Rodriguez-Leyva D, Dupasquier CM, McCullough R, Pierce GN. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Can J Cardiol. 2010;26(9):489-496.21076723
18. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90(2):288-297.19515737
19. Prasad K. Flaxseed and cardiovascular health. J Cardiovasc Pharmacol. 2009;54(5):369-377.19568181
20. Dewell A, Marvasti FF, Harris WS, Tsao P, Gardner CD. Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. J Nutr. 2011;141(12):2166-2171.22031659
21. Faintuch J, Bortolotto LA, Marques PC, Faintuch JJ, Franca JI, Cecconello I. Systemic inflammation and carotid diameter in obese patients: Pilot comparative study with flaxseed powder and cassava powder. Nutr Hosp. 2011;26(1):208-213.21519749
22. Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 2011;105(3):417-427.20875216
23. Fukumitsu S, Aida K, Shimizu H, Toyoda K. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutr Res. 2010;30(7):441-446.20797475
24. Pan A, Demark-Wahnefried W, Ye X, et al. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Br J Nutr. 2009;101(8):1145-1149.18775100
25. Ogborn MR, Nitschmann E, Weiler H, Leswick D, Bankovic-Calic N. Flaxseed ameliorates interstitial nephritis in rat polycystic kidney disease. Kidney Int. 1999;55(2):417-423.9987066
26. Hall AV, Parbtani A, Clark WF, et al. Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. Am J Kidney Dis. 1993;22(2):326-332.8352261
27. Mozaffarian D. Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence. Altern Ther Health Med. 2005;11(3):24-30.15945135
28. Wang L, Chen J, Thompson LU. The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative breast cancer xenografts is attributed to both its lignan and oil component. Int J Cancer. 2005;116(5):793-798.15849746
29. Schabath MB, Hernandez LM, Wu X, Pillow PC, Spitz MR. Dietary phytoestrogens and lung cancer risk. JAMA. 2005;294(12):1493-1504.16189362
30. Bommareddy A, Arasada BL, Mathees DP, Dwivedi C. Chemoprotective effects of dietary flaxseed on colon tumor development. Nutr Cancer. 2006;54(2):216-222.16898866
31. Saadatian-Elahi M, Norat T, Goudable J, Riboli E. Biomarkers of dietary fatty acid intake and the risk of breast cancer: a meta-analysis. Int J Cancer. 2004;111(4):584-591.15239137
32. Thompson LU, Chen JM, Li T, Strasser-Weippl K, Goss PE. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res. 2005;11(10):3828-3835.15897583
33. Flaxseed slows prostate tumor growth. Clin Advis. 2007;10(8):12.
34. Demark-Wahnefried W, Price DT, Polascik TJ, et al. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology. 2001;58(1);47-52.11445478
35. Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT. Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Urology. 2004;63(5):900-904.15134976
36. Nash GK. Does dietary flaxseed oil have a role in prostate cancer? Clin Advis. 2007;10(3):119-120.
37. Demark-Wahnefried W, Polascik TJ, George SL, et al. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3577-3587.19064574
38. Zhang W, Wang X, Liu Y, et al. Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. J Med Food. 2008;11(2):207-214.18358071
39. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr. 2008;27(1):51-58.18460481
40. Dahl WJ, Lockert EA, Cammer AL, Whiting SJ. Effects of flax fiber on laxation and glycemic response in healthy volunteers. J Med Food. 2005;8(4):508-511.16379563
41. Lemay A, Dodin S, Kadri N, Jacques H, Forest JC. Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol. 2002;100(3):495-504.12220769
42. Bloedon LT, Balikai S, Chittams J, et al. Flaxseed and cardiovascular risk factors: results from a double blind randomized, controlled clinical trial. J Am Coll Nutr. 2008;27(1):65-74.18460483
43. Zhang W, Wang X, Liu Y, et al. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolemic subjects. Br J Nutr. 2008;99(6):1301-1309.18053310
44. Barre DE, Mizier-Barre KA, Griscti O, Hafez K. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. J Oleo Sci. 2008;57(5):269-273.18391475
45. Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl. 2011;8(3):257-265.22432725
46. Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: A randomized crossover design. Nutr J. 2011;10:44.21554710
47. Taylor CG, Noto AD, Stringer DM, Froese S, Malcolmson L. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J Am Coll Nutr. 2010;29(1):72-80.20595648
48. Prasad K. Hypocholesterolemic and atherosclerotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis. 2005;179(2):269-275.15777541
49. Ibrügger S, Kristensen M, Mikkelsen MS, Astrup A. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Appetite. 2012;58(2):490-495.22245724
50. Young GS, Conquer JA, Thomas R. Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev. 2005;45(5):549-558.16188207
51. Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of attention deficit hyperactivity disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):17-21.16314082
52. Sarris J, Mischoulon D, Schweitzer I. Omega-3 for bipolar disorder: Meta-analyses of use in mania and bipolar depression. J Clin Psychiatry. 2012;73(1):81-86.21903025
53. Gracious BL, Chirieac MC, Costescu S, Finucane TL, Youngstrom EA, Hibbeln JR. Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar Disord. 2010;12(2):142-154.20402707
54. Neukam K, De Spirt S, Stahl W, et al. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition. Skin Pharmacol Physiol. 2011;24(2):67-74.21088453
55. De Spirt S, Stahl W, Tronnier H, et al. Intervention with flaxseed and borage oil supplements modulates skin condition in women. Br J Nutr. 2009;101(3):440-445.18761778
56. Yarnell E, Abascal K. Lupus erythematosus and herbal medicine. Altern Complement Ther. 2008;14(1):9-12.
57. Clark WF, Muir AD, Westcott ND, Parbtani A. A novel treatment for lupus nephritis: lignan precursor derived from flax. Lupus. 2000;9(6):429-436.10981647
58. Clark WF, Kortas C, Heidenheim AP, Garland J, Spanner E, Parbtani A. Flaxseed in lupus nephritis: a two-year nonplacebo-controlled crossover study. J Am Coll Nutr. 2001;20(2 suppl):143-148.11349937
59. Dodin S, Lemay A, Jacques H, Légaré F, Forest JC, Mâsse B. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab. 2005;90(3):1390-1397.15613422
60. Lewis JE, Nickell LA, Thompson LU, Szalai JP, Kiss A, Hilditch JR. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause. 2006;13(4):631-642.16837885
61. Pruthi S, Qin R, Terstreip SA, et al. A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North central cancer treatment group N08C7. Menopause. 2012;19(1):48-53.21900849
62. Simbalista RL, Sauerbronn AV, Aldrighi JM, Areas JA. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. J Nutr. 2010;140(2):293-297.20007337
63. Coulman KD, Liu Z, Michaelides J, Quan Hum W, Thompson LU. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. Mol Nutr Food Res. 2009;53(11):1366-1375.19824016
64. Fernandes FS, de Souza AS, do Carmo Md, Boaventura GT. Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory. Nutrition. 2011;27(10):1040-1047.21439792
65. Adolphe JL, Whiting SJ, Juurlink BH, et al. Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. Br J Nutr. 2010;103(7):929-938.20003621
66. Moussally K, Berard A. Exposure to specific herbal products during pregnancy and the risk of low birth weight. Altern Ther Health Med. 2012;18(2):36-43.22516883
67. Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG. 2002;109(3):227-235.11950176
68. Knudsen VK, Hansen HS, Osterdal ML, Mikkelsen TB, Mu H, Olsen SF. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomized controlled trial. BJOG. 2006;113(5):536-543.16579802
69. Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM, Jenkins DJ. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr. 1995;61(1):62-68.7825540
70. Lezaun A, Fraj J, Colás C, et al. Anaphylaxis from linseed. Allergy. 1998;53(1):105-106.9491240
71. Alonso L, Marcos ML, Blanco JG, et al. Anaphylaxis caused by linseed (flaxseed) intake. J Allergy Clin Immunol. 1996;98(2):469-470.8757228
72. Zuskin E, Kanceljak B, Schachter EN, et al. Immunological findings in hemp workers. Environ Res. 1992;59(2):350-361.1464288
73. Holman RT, et al. A case of human linolenic acid deficiency involving neurological abnormalities. Am J Clin Nutr. 1982;35(3):617-623.6801965
74. Khanna D, Khanna PP, Fitzgerald JD, et al; American College of Rheumatology. 2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and anti-inflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken). 2012; 64(10):1447-1461.23024029
75. Álvarez-Perea A, Alzate DP, Maldonado AD, Baeza ML. Anaphylaxis caused by flaxseed. J Investig Allergol Clin Immunol. 2013;23(6):446-447.24459826
76. Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr Res 2013;33(5):367-375.23684438
77. Zong G, Demark-Wahnefried W, Wu H, Lin X. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. Eur J Nutr. 2013;52(2):1547-1551.23179200
78. Rodriguez-Leyva D, Weighell W, Edel AL, et al. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013;62(6):1081-1089.24126178
79. Au MM1, Goff HD, Kisch JA, Coulson A, Wright AJ. Effects of soy-soluble fiber and flaxseed gum on the glycemic and insulinemic responses to glucose solutions and dairy products in healthy adult males. J Am Coll Nutr. 2013;32(2):98-110.24015717
80. Kontogianni MD, Vlassopoulos A, Gatzieva A, Farmaki AE, Katsiougiannis S, Panagiotakos DB, Kalogeropoulos N, Skopouli FN. Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults. Metabolism. 2013;62(5):686-693.23347535
81. Wong H, Chahal N, Manlhiot C, Niedra E, McCrindle BW. Flaxseed in pediatric hyperlipidemia: a placebo-controlled, blinded, randomized clinical trial of dietary flaxseed supplementation for children and dolescents with hypercholesterolemia. JAMA Pediatr. 2013;167(8):708-713.23733031
82. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth. ScienceDaily, October 29, 2008. Accessed June 5, 2014.
83. Caligiuri SP, Aukema HM, Ravandi A, Guzman R, Dibrov E, Pierce GN. Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an α-linolenic acid-induced inhibition of soluble epoxide hydrolase. Hypertension. 2014;64:53-59.24777981
84. American Diabetes Association. 5. Facilitating behavior change and well-being to improve health outcomes: Standards of medical care in diabetes-2021. Diabetes Care. 2021;44(suppl 1):S53-S72. doi:10.2337/dc21-S00533298416
85. Ristic-Medic D, Perunicic-Pekovic G, Rasic-Milutinovic Z, et al. Effects of dietary milled seed mixture on fatty acid status and inflammatory markers in patients on hemodialysis. Scientific World Journal. 2014;22:563576.24578648
86. Khalesi S, Irwin C, Schubert M. Flaxseed comsumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. J Nutr. 2015;145:758-765.25740909
87. Edel AL, Rodriguez-Leyva D, Maddaford TG, Caligiuri SP, Austria JA, Weighell W, Guzman R, Aliani M, Pierce GN. Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease. J Nutr. 2015;145:749-757.25694068
88. Ramos CI, Andrade de Lima AF, Grilli DG, Cuppari L. The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients. J Renal Nutr. 2015;25(1):50-56.25238699
89. Kawakami Y, Yamanaka-Okumua H, Naniwa-Kuroki Y, Sakuma M, Taketani Y, Takeda E. Flaxseed oil intake reduces serum small dense low-density lipoprotein concentration sin Japanese men: a randomized, double-blind, crossover study. Nutr J. 2015;14:39.25896182
90. Torkan M, Entezari MH, Siavash M. Effect of flaxseed on blood lipid level in hyperlipidemic patients. Rev Recent Clin Trials. 2015;10(1):61-67.25612882
91. Melina V, Craig W, Levin S. Position of the Academy of Nutrition and Dietetics: Vegetarian diets. J Acad Nutr Diet. 2016;116(12):1970-1980. doi:10.1016/j.jand.2016.09.02527886704
92. Stuenkel CA, Davis SR, Gompel A, et al. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011.26444994
93. Mirfatahi M, Tabibi H, Nasrollahi A, Hedayati M. Effects of flaxseed oil on serum lipids and lipoproteins in hemodialysis patients. IJKD. 2016;10:405-12.27904000
94. Kang Y, Park SY, Noh S, Kim J, Seo B, Kwon OY, Kwon HS, Cho YS, Moon HB, Kim TB. Case report: a first case of flaxseed-induced anaphylaxis in Korea. Medicine (Baltimore). 2017;96(49):e8220.29245212
95. Imbruvica (ibrutinib) [product monograph]. Toronto, Ontario, Canada: Janssen Inc; November 2014.
96. Imbruvica (ibrutinib) [prescribing information]. Horsham, PA: Janssen Biotech Inc; July 2014.
97. Nonhormonal management of menopause-associated vasomotor symptoms: 2015 position statement of The North American Menopause Society. Menopause. 2015;22(11):1155-1172.26382310
98. Takenaka T, Nagano M, Yamashita K, Kikuchi K. Flaxseed oil stimulates gynecomastia. BMJ Case Rep. 2020;13(12):e237948.33303502
99. Yuksel N, Evaniuk D, Huang L, et al. Guideline no. 422a: Menopause: Vasomotor symptoms, prescription therapeutic agents, complementary and alternative medicine, nutrition, and lifestyle [published correction appears in J Obstet Gynaecol Can. 2022;44(2):227]. J Obstet Gynaecol Can. 2021;43(10):1188-1204.e1. doi:10.1016/j.jogc.2021.08.00334390867
100. Villarreal-Renteria AI, Herrera-Echauri DD, Rodríguez-Rocha NP, et al. Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2022;70:102852. doi:10.1016/j.ctim.2022.10285235843472

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