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Can regular and lispro insulin (Humalog) be mixed?

Medically reviewed by Carmen Pope, BPharm. Last updated on June 18, 2024.

Official Answer by Drugs.com

It is important to always check the compatibility of insulins before you mix them.

In general, the rule: “ Clear before cloudy, draw the fastest insulin first”, should be followed.

If you need to mix regular with lispro insulin (Humalog):

Some insulins cannot be combined. For example:

Longer-acting insulins contain added buffers that make them last longer in the body, and these can settle at the bottom of a vial or precipitate out when mixed with other insulins (or mixed in the wrong order).

Do not shake a bottle of insulin. Instead, gently turn it up and down about 20 times or roll it in your hands slowly.

Related questions

Lispro insulin

Lispro insulin has a rapid onset of action and peaks in one half the time and double the concentration of a comparable dose of regular insulin. It should be injected immediately before eating or with a meal.

Regular insulin

References

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