Is Probuphine better than Sublocade?
Probuphine and Sublocade are long-acting forms of buprenorphine, but the Probuphine brand has been discontinued in the United States. There was no evidence that one is better than the other. They were both used in long-term medication-assisted treatment (MAT) for opioid use disorder (OUD).
Probuphine was implanted under the skin for several months, and Sublocade is a monthly injectable. Both of these drugs improved recovery from OUD because they eliminated the possibility of missing daily doses of buprenorphine that may lead to a relapse.
Buprenorphine is an opioid drug, but when used in treatment of opioid addiction at the proper dose, it can block the effects of stronger opioids like heroin. Taken by mouth on a daily basis, implanted or injected, the constant low dose decreases the cravings caused by addiction. Along with counseling and support therapies, buprenorphine as prescribed can reduce OUD and the risk of overdose and death from OUD.
Both Probuphine and Sublocade increase compliance of OUD treatment. Patients do not need to show up for daily treatment at a clinic. They both reduce the cravings for opioids and reduce withdrawal symptoms.
- Probuphine was approved by the U.S. Food and Drug Administration (FDA) in 2016. It was the first long-acting buprenorphine. It is approved to treat OUD after a patient has been stable on daily, oral buprenorphine. To take Probuphine, 4 one-inch-long rods are inserted under the skin of the upper arm. The rods give off a low and steady dose of buprenorphine over 6 months. After 6 months, the rods must be removed. New rods may be placed in the other arm for continued treatment if needed for one more treatment course. Insertion and removal of the rods must be done by a trained and certified health care provider.
- Sublocade is buprenorphine injected once per month under the skin. The FDA approved this treatment in 2017. It is approved for OUD patients who have had at least one dose of transmucosal buprenorphine and a one-hour observation period to confirm tolerability. After Sublocade is injected, a deposit forms under the skin that gives off a slow and steady amount of the medicine. It comes in a prefilled syringe that must be injected by a trained and certified health care provider.
Both drugs have similar side effects common to all buprenorphine drugs. These include, among others:
- Constipation
- Headache
- Nausea
- Vomiting
Probuphine may cause insertion site reactions. There is also some risk of the rods extruding or migrating under the skin.
Sublocade may cause injection site irritation or itching.
You can decide which drug fits your needs best after discussing the risks and benefits with your certified OUD health care provider.
Related questions
- What are the different brands of buprenorphine?
- Is buprenorphine an opiate / narcotic?
- What is the difference between Sublocade and Brixadi?
References
- Sublocade Injection. https://www.drugs.com/sublocade.html
- Sublocade FDA Approval History. https://www.drugs.com/history/sublocade.html
- Sublocade Package Insert. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/209819s031lbl.pdf
- Probuphine Implant. https://www.drugs.com/probuphine.html
Read next
How and where is the Sublocade injection given?
Sublocade is administered as an injection just under the skin (subcutaneous) of your stomach (abdomen), thigh, buttock, or back of the upper arm. After the first two injections, you will receive it monthly (with at least 26 days between doses). Continue reading
Is Sublocade covered by Medicaid?
Most patients with Medicaid typically pay low or no cost for Sublocade (buprenorphine) if it is a preferred drug treatment by their state health plan. Your health plan and costs are determined by your state Medicaid program. Continue reading
Who makes Sublocade in the U.S?
Sublocade (buprenorphine) is made by Indivior. Sublocade (buprenorphine) is an extended-release, once-monthly subcutaneous (under the skin) injection that steadily releases buprenorphine into your bloodstream for the treatment of opiate dependence (opioid use disorder). Sublocade is only given by a healthcare provider. Serious harm or death could result if administered intravenously. Continue reading
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Drug information
Related support groups
- Sublocade (20 questions, 41 members)
- Probuphine (5 questions, 5 members)