How long do you take Nerlynx for?
Nerlynx is taken for up to a year when it is used to treat early-stage HER2-positive breast cancer, unless unacceptable toxicity or disease progression occurs. When Nerlynx is given to treat advanced-stage or metastatic HER2-positive breast cancer, it is taken for as long as you are getting benefits from the drug (for example your cancer has not got worse while you are taking Nerlynx) and you are tolerating it okay with no unacceptable side effects.
Nerlynx (neratinib) is a targeted treatment that is taken by mouth to treat early-stage, advanced, or metastatic HER-2 positive breast cancer. The recommended dose of Nerlynx is 240 mg (6 tablets) once per day with food.
For early-stage Her-2 positive breast cancer, it is given once a day, every day for up to one year unless your breast cancer recurs. For advanced or metastatic breast cancer it is given every day of a 21-day cycle (with capecitabine [Xeloda] given on days 1-14 of the cycle) for as long as you are getting benefits from the medicines and aren’t having troubling side effects.
If you experience toxicity with Nerlynx (such as excessive diarrhea or liver toxicity) you dose may be temporarily stopped until you recover and then restarted at a lower dose, or Nerlynx may be discontinued completely if the toxicity is too severe.
References
- Nerlynx Breastcancer.org 2020 https://www.breastcancer.org/treatment/targeted_therapies/nerlynx#:~:text=Nerlynx%20is%20a%20pill%20taken,take%20Nerlynx%20for%201%20year
- Nerlynx (neratinib)https://www.drugs.com/pro/nerlynx.html
- Nerlynx (neratinib) Nerlynx.com https://nerlynx.com/
Read next
What’s the difference between tucatinib and neratinib?
Tucatinib (Tukysa) is used in the treatment of more advanced or metastatic HER2+ breast cancer or HER2+ colorectal cancer, while Neratinib (Nerlynx) is used in the treatment of both early-stage and advanced or metastatic HER2+ breast cancer, but is not approved for use in colorectal cancer. Continue reading
When does diarrhea start when taking Nerlynx?
Diarrhea can start as soon as you start taking Nerlynx – 93% of women experienced diarrhea within the first month of treatment (average time to the onset of diarrhea was 8 days) in trials that did not require anti-diarrheal medication to be taken at the same time. However, the risk of diarrhea developing is greatly reduced in those who take loperamide, an antidiarrheal medication, at the same time as Nerlynx. Continue reading
Is Nerlynx (neratinib) a chemo drug?
Nerlynx (neratinib) is not a chemo drug it is a type of targeted treatment that works by irreversibly binding to and inhibiting specific receptors on the surface of cancer cells called HER2, HER4, and EGFR receptors, which receive signals that tell cancer to grow and spread. Continue reading
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