What drugs are contained in the HIV treatment Symtuza?

Symtuza is a four-drug combination used for treatment of HIV-1 infection in adults. It contains:

• Darunavir (Prezista) - A protease inhibitor that stops HIV replication and helps to provide a high barrier to drug resistance, meaning it may keep on working even if the HIV virus has changed (mutated).
• Cobicistat (Tybost) - An antiviral booster that reduces the activity of enzymes in the liver that break down certain HIV medicines so they can be used more safely and effectively at lower doses.
• Emtricitabine (Emtriva) - A nucleoside analog reverse transcriptase inhibitor that helps prevent HIV from multiplying in the body.
• Tenofovir alafenamide (Vemlidy) - A nucleoside analog reverse transcriptase inhibitor that helps prevent HIV from multiplying in the body.

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Who Can Take Symtuza?

Symtuza is indicated as a complete regimen for the treatment of HIV-1 infection in adults:

• who have no prior antiretroviral treatment history or
• who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6 months and have no known substitutions associated with resistance to darunavir or tenofovir.

Learn more about HIV and AIDS: HIV and AIDS Information Center

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