What is the difference between Amjevita and Humira?
Amjevita (adalimumab-atto) is a biosimilar to Humira (adalimumab), an anti-TNF-α monoclonal antibody used for the treatment of multiple conditions including rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, and hidradenitis suppurativa.
A biosimilar is a product that is highly similar to an FDA-approved biologic, known as the reference product. Biosimilars have no clinically meaningful differences in safety, purity or potency compared to the reference product.
Amjevita (adalimumab-atto) was the first Humira (adalimumab) biosimilar approved by the FDA.
FDA approved biosimilars to Humira include:
- Amjevita (adalimumab-atto)
- Cyltezo (adalimumab-adbm)
- Hyrimoz (adalimumab-adaz)
- Hadlima (adalimumab-bwwd)
- Abrilada (adalimumab-afzb)
- Hulio (adalimumab-fkjp)
- Yusimry (adalimumab-aqvh)
- Idacio (adalimumab-aacf)
- Yuflyma (adalimumab-aaty)
For more information, details and comparison tables of brands of Humira see adalimumab.
The approved indications for Humira and Amjevita are not the same.
Like Humira, Amjevita is used for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa and Uveitis.
Indications may also differ across age groups groups.
The following table compares the approved indications for Humira and Amjevita:
| Indication | Humira | Amjevita |
|---|---|---|
| Rheumatoid Arthritis (RA) | adults | adults |
| Juvenile Idiopathic Arthritis (JIA) |
patients 2 years of age and older |
patients 2 years of age and older |
| Psoriatic Arthritis (PsA) | adults | adults |
| Ankylosing Spondylitis (AS) | adults | adults |
| Crohn’s Disease (CD) | patients 6 years of age and older | patients 6 years of age and older |
| Ulcerative Colitis (UC) | patients 5 years of age and older | adults |
| Plaque Psoriasis (Ps) | adults | adults |
| Hidradenitis Suppurativa (HS) | patients 12 years of age and older | adults |
| Uveitis (UV) | patients 2 years of age and older | adults |
Amjevita is not approved as an interchangeable product at the pharmacy, meaning the pharmacist needs approval from the prescribing doctor to substitute Amjevita for Humira if not specified on the prescription.
Amjevita and Humira are both administered via subcutaneous injection.
- Amjevita is available as a prefilled syringe (80 mg/0.8 mL, 40 mg/0.8 mL, 40 mg/0.4 mL, 20 mg/0.4 mL, 20 mg/0.2 mL, 10 mg/0.2 mL)and SureClick® autoinjector (80 mg/0.8 mL, 40 mg/0.8 mL, 40 mg/0.4 mL).
- Humira is available as a single-dose prefilled pen, prefilled syringe, and single-dose vial.
See What Are Biosimilars? Top Facts You May Not Know
Related questions
- What are the new drugs for rheumatoid arthritis (RA)?
- What medications are known to cause hair loss?
- Can you take Humira with antibiotics?
References
- U.S. Food and Drug Administration. HUMIRA Product Label. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/125057s417lbl.pdf [Accessed June 26, 2023]
- U.S. Food and Drug Administration. AMJEVITA Product Label. Available at https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761024Orig1s011lbl.pdf [Accessed June 26, 2023]
- U.S. Food and Drug Administration. What is a Biosimilar? Available at https://www.fda.gov/media/108905/download [Accessed March 2, 2021]
Read next
Cosentyx vs Humira: How do they compare?
Both Cosentyx and Humira are available as subcutaneous injections (which means given under the skin) and may be used to treat certain inflammatory conditions such as plaque psoriasis, psoriatic arthritis, hidradenitis suppurativa, and ankylosing spondylitis. Cosentyx is also available as an IV injection that can be administered by a healthcare provider. After an initial loading dose, Humira is given every two weeks and Cosentyx every four weeks. Continue reading
Skyrizi vs Humira for plaque psoriasis - How do they compare?
In a head-to-head clinical study between Skyrizi and Humira, researchers found that Skyrizi was better than Humira at clearing moderate-to-severe plaque psoriasis in adults. At 16 weeks, 72% of patients given Skyrizi achieved 90% clearer skin compared to 47% of patients given Humira, a statistically significant outcome. Continue reading
Is Amjevita interchangeable with Humira?
Amjevita is not yet interchangeable with Humira, and the pharmacist must get approval from your doctor before they can substitute it for Humira. The approved interchangeable biosimilars for Humira are Abrilada, Amjevita, Cyltezo, Hadlima, Hulio, Hyrimoz, and Simlandi according to the FDA Purple Book as of March 2025. Continue reading
See also:
Related medical questions
- What is the difference between Cyltezo and Humira?
- What are the new drugs for plaque psoriasis?
- What are biologic drugs and how do they work?
- What biosimilars have been approved in the United States?
- New 'Biosimilars' may help Reduce Medication Costs
- How much does Humira cost without insurance?
- What happens when you stop taking Humira?
- Does Humira cause weight gain or weight loss?
- How long does it take for Humira to work?
- How long can Humira be out of the fridge?
- What food should I avoid while taking Humira?
- What are Monoclonal Antibodies and how do they work?
- How long can you stay on Humira?
- Biosimilars vs Biologics: What are they and how do they compare?
- Can you drink alcohol while taking Humira?
- Can I take Humira after covid vaccine?
- Is Humira an immunosuppressant?
- How do you inject Humira?
- Does Humira make you feel tired?
- Does Humira cause hair loss?
- What's the difference between Cimzia and Humira?
- Does Humira cause muscle spasms?
- Is Humira good for treating hidradenitis suppurativa?
- Who are the actors in the Humira commercial?
- What causes Plaque Psoriasis?
- Humira and Pregnancy: What should I know?
Drug information
Related support groups
- Adalimumab (15 questions, 14 members)
- Humira (69 questions, 370 members)
- Amjevita (8 questions, 6 members)
- Rheumatoid Arthritis (337 questions, 1,333 members)
- Ulcerative Colitis (75 questions, 188 members)
- Crohn's Disease (62 questions, 286 members)
- Plaque Psoriasis (94 questions, 69 members)
- Ankylosing Spondylitis (59 questions, 212 members)
- Psoriatic Arthritis (91 questions, 282 members)
- Juvenile Idiopathic Arthritis (19 questions, 17 members)