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Juvenile arthritis

Medically reviewed by Last updated on Mar 23, 2023.

What is Juvenile arthritis?

Harvard Health Publishing

Arthritis involves inflammation of the joints that causes pain and swelling. Although many people believe arthritis is a disease of old age, various forms of arthritis can affect just about anyone at any age. When arthritis occurs in children younger than age 16, it is called juvenile arthritis. According to the Arthritis Foundation, about 300,000 children in the United States have some form of the disease.

The most common forms of juvenile arthritis are:

There are several subcategories of juvenile idiopathic arthritis, including:


Symptoms vary depending on the child and the specific disorder. Common symptoms include:

  • one or more joints that are persistently swollen and tender, or possibly red and warm to the touch
  • pain when moving joints, although many young children never complain of pain
  • stiffness or decreased ability to move joints, especially when waking
  • limping
  • joints that look knobby or deformed
  • bent posture or limbs.

Other symptoms can include:

  • uneven (asymmetric) growth patterns (one leg longer than the other, for example)
  • blurry vision, eye pain or redness
  • low-grade fever
  • skin rash
  • fatigue
  • irritability
  • chest pain
  • general complaints of pain.


Juvenile arthritis is difficult to diagnose because many diseases have similar symptoms, and there is no single test that pinpoints the diagnosis. If your child shows signs of juvenile arthritis, you likely will be referred to a pediatric rheumatologist. The rheumatologist will look at your child's medical history to find clues. For example, one of the primary diagnostic criteria for juvenile idiopathic arthritis is joint inflammation that has lasted for at least six weeks.

Your doctor may order blood tests to look for antibodies that commonly form in people with some types of arthritis, although these antibodies are often absent in children. X-rays may be performed to look for damage to cartilage or, in severe cases, bone. Other tests may also be done to look for other conditions that could explain the symptoms, such as tests for infection. Lyme disease is an infectious cause of arthritis that may affect children and mimic juvenile idiopathic arthritis.

Expected duration

Juvenile arthritis usually is a lifelong condition. However, for many people, symptoms gradually lessen or disappear as they enter adulthood.


Because no one knows what causes juvenile arthritis, there is no way to prevent it.


The main goal of treatment is to control inflammation to stop further damage to the joints, and to control symptoms so that the child can function well. Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually the first medications tried to relieve joint inflammation. They work by decreasing the amount of an enzyme found in affected joints that promotes inflammation. This same enzyme, however, helps to protect the stomach, so NSAIDs often cause stomach irritation and ulcers. Low doses of NSAIDs are available over-the-counter, including ibuprofen (Advil, Motrin and other brand names) and naproxen (Naprosyn, Aleve and others). Celecoxib (Celebrex) is a newer prescription drug, called a COX-2 inhibitor that is thought to be safer for the stomach because it does not have as much of an effect on the enzyme that protects the stomach.

In moderate to severe cases, children with juvenile arthritis may be treated with more powerful medications or a combination of medicines. Corticosteroids (such as prednisone) are fast-acting, anti-inflammatory agents that may be used to stop dangerous inflammation, such as when the lining of the heart has become inflamed (pericarditis) or to stabilize a child in an acute stage of the disease. However, these drugs can have very serious side effects, including weight gain, weakened bones, an increased susceptibility to infections and interference with growth. They usually are prescribed for only a short time. They must be taken exactly as directed.

Other drugs, called disease modifying anti-rheumatic drugs (DMARDs) — such as methotrexate (Rheumatrex and others) — act more slowly, but often provide relief if other medications have failed. These drugs can cause liver damage or other complications, so doctors will carefully monitor blood tests in children taking DMARDs. Other medications may be effective, including hydroxychloroquine (Plaquenil), sulfasalazine (Azulfidine), leflunomide (Arava), azathioprine (Imuran) and cyclosporine (Neoral, Sandimmune). Thalidomide may be effective for certain children with JRA, but care must be taken to avoid pregnancy while taking this drug and it can cause nerve damage.

Newer, injectable treatments, including adalimumab (Humira), etanercept (Enbrel), abatacept (Orencia) and tocilizumab (Actemra) may be effective for juvenile idiopathic arthritis. Infliximab (Remicade), anakinra (Kineret), canakinumab (Ilaris) and rituximab (Rituxan) can also be highly effective for some children with juvenile idiopathic arthritis. Surgery sometimes is required if joint damage is severe or joint deformity has developed.

Children with juvenile arthritis should be encouraged to maintain as normal a life as possible. Although there may be pain, exercise is important to help the joints keep moving and functioning well. Once symptoms are under control, it's good for your child to engage in usual play and sports activities. In severe cases, physical therapy may be recommended to keep the joints moving as freely as possible.

Tutoring or special attention from teachers may be needed if the child misses many weeks of school due to illness. Also, counseling might be recommended to help the child deal with the emotional aspects of having a long-lasting (chronic) illness.

When to call a professional

Call a health care professional if a child develops fever or rash along with symptoms of arthritis, such as persistent joint pain, swollen joints, limping and limited motion.


Because the symptoms and damage caused by juvenile arthritis can vary greatly, the outlook also varies significantly. Some types of arthritis have periods of flaring up and periods when symptoms subside. Treatment can control symptoms for most people, and some children "outgrow" the illness. However, severe forms of the disease can cause growth problems if the growth plates in the long bones are damaged. Children who are very ill also can miss long periods of school, and joint damage can cause long-term joint problems. In addition, the medications used to treat juvenile arthritis can cause other problems, including stomach ulcers, weakened bones and liver damage.

Additional info

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Arthritis Foundation

American College of Rheumatology

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.