Xeljanz XR and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Xeljanz XR (tofacitinib).
Tofacitinib Food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
MONITOR: Grapefruit juice may increase the plasma concentrations of tofacitinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Until more information is available, some authorities recommend avoiding consumption of grapefruit juice during tofacitinib therapy (Canada). Patients receiving tofacitinib therapy who ingest grapefruits or grapefruit juice should be monitored for adverse effects and undue fluctuations in plasma drug levels.
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Tofacitinib High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
tofacitinib - hyperlipidemia
Treatment with tofacitinib was associated with dose-dependent increases in lipid parameters (including total cholesterol, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol); maximum effects generally occurred within 6 weeks. Lipid parameters should be assessed about 4 to 8 weeks after initiation of therapy. Patients should be managed according to clinical guidelines for the management of hyperlipidemia.
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Xeljanz XR drug interactions
There are 672 drug interactions with Xeljanz XR (tofacitinib).
Xeljanz XR disease interactions
There are 13 disease interactions with Xeljanz XR (tofacitinib) which include:
- cardiovascular risk
- malignancy
- thrombosis
- infections
- tuberculosis
- viral reactivation
- cytopenias
- diabetes
- GI obstruction
- GI perforation
- hepatic disorder
- hyperlipidemia
- renal disease
More about Xeljanz XR (tofacitinib)
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- Drug class: antirheumatics
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.