Ranolazine and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with ranolazine.
Ranolazine Food
Major Food Interaction
GENERALLY AVOID: Grapefruit and grapefruit juice may significantly increase the plasma concentrations of orally administered ranolazine. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Because ranolazine prolongs QT interval in a dose-dependent manner, high plasma levels of ranolazine may increase the risk of ventricular arrhythmias such as ventricular tachycardia, ventricular fibrillation, and torsade de pointes.
MANAGEMENT: Patients treated with ranolazine should avoid consumption of grapefruit juice and other grapefruit products if possible. Otherwise, the dosage of ranolazine should be limited to 500 mg twice a day.
References (1)
- (2006) "Product Information. Ranexa (ranolazine)." Calmoseptine Inc
Switch to consumer interaction data
Ranolazine drug interactions
There are 548 drug interactions with ranolazine.
Ranolazine disease interactions
There are 3 disease interactions with ranolazine which include:
Report options
More about ranolazine
- ranolazine consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (91)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: antianginal agents
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Bisoprolol
Bisoprolol belongs to a group of drugs called beta-blockers and is used to treat hypertension (high ...
Isosorbide mononitrate
Isosorbide mononitrate is used to prevent angina attacks (chest pain) by dilating blood vessels ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Diltiazem
Diltiazem is used to treat high blood pressure, angina and certain heart rhythm disorders. Included ...
Nifedipine
Nifedipine is used to lower hypertension (high blood pressure) and to treat angina (chest pain) ...
Enoxaparin
Enoxaparin systemic is used for acute coronary syndrome, angina, deep vein thrombosis, deep vein ...
Heparin
Heparin injection is used to treat and prevent blood clots in the veins, arteries, or lungs. Learn ...
Atenolol
Atenolol is used to treat angina (chest pain) and hypertension (high blood pressure). Learn about ...
Nitroglycerin
Nitroglycerin systemic is used for anal fissure and fistula, angina, angina pectoris prophylaxis ...
Propranolol
Propranolol is a beta-blocker that is used to treat tremors, chest pain, high blood pressure, heart ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
