Methylnaltrexone and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with methylnaltrexone.
Methylnaltrexone Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the rate and extent of absorption of methylnaltrexone following oral administration. When a single 450 mg oral dose of methylnaltrexone was administered with a high-fat breakfast (approximately 800 to 1000 calories; 60% from fat, 25% from carbohydrate, and 15% from protein) in healthy study subjects, methylnaltrexone peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 60% and 43%, respectively, while time to reach Cmax delayed by 2 hours.
MANAGEMENT: Oral methylnaltrexone should be taken with water on an empty stomach at least 30 minutes before the first meal of the day.
References (1)
- (2008) "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories
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Methylnaltrexone drug interactions
There are 24 drug interactions with methylnaltrexone.
Methylnaltrexone disease interactions
There are 3 disease interactions with methylnaltrexone which include:
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- Drug class: peripheral opioid receptor antagonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
