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Amitriptyline/chlordiazepoxide and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with amitriptyline / chlordiazepoxide.

Moderate

chlordiazePOXIDE food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References

  1. Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
  3. "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
  4. "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
View all 4 references
Moderate

Obesity

Moderate Potential Hazard, Moderate plausibility

benzodiazepines - obesity

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.

References

  1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Valium (diazepam)." Roche Laboratories PROD (2002):
  3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories PROD (2002):
  4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories PROD (2001):
  5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation PROD (2001):
  6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn PROD (2001):
  7. "Product Information. Dalmane (flurazepam)." Roche Laboratories PROD (2001):
  8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical PROD (2001):
  9. "Product Information. Klonopin (clonazepam)." Roche Laboratories PROD (2001):
  10. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
  11. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories PROD (2001):
  12. "Product Information. Doral (quazepam)." Wallace Laboratories PROD (2001):
  13. "Product Information. Versed (midazolam)." Roche Laboratories PROD (2001):
  14. American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
View all 14 references

Amitriptyline/chlordiazepoxide drug interactions

There are 761 drug interactions with amitriptyline / chlordiazepoxide.

Amitriptyline/chlordiazepoxide disease interactions

There are 31 disease interactions with amitriptyline / chlordiazepoxide which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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