Cymbalta Drug Interactions
Currently displaying a list of 633 drugs known to interact with Cymbalta (duloxetine).
- 109 major drug interactions
- 501 moderate drug interactions
- 23 minor drug interactions
Medications known to interact with Cymbalta
Note: Showing generic names only.
5
A
- abametapir topical
- abciximab
- abiraterone
- abrocitinib
- acalabrutinib
- acetazolamide
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- ado-trastuzumab emtansine
- albuterol
- aldesleukin
- alefacept
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- alteplase
- aluminum carbonate
- aluminum hydroxide
- amifampridine
- amiloride
- amiodarone
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- anagrelide
- anakinra
- anisindione
- anistreplase
- antithrombin (recombinant)
- antithrombin iii
- apixaban
- apomorphine
- apraclonidine ophthalmic
- ardeparin
- arformoterol
- argatroban
- aripiprazole
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atomoxetine
- avapritinib
- azatadine
- azelastine nasal
B
- baclofen
- bedaquiline
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- berotralstat
- betrixaban
- bimekizumab
- biperiden
- bismuth subsalicylate
- bitolterol
- bivalirudin
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromfenac
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabozantinib
- caffeine
- calaspargase pegol
- calcium carbonate
- canakinumab
- cangrelor
- cannabidiol
- cannabis
- caplacizumab
- capmatinib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- celecoxib
- cenobamate
- cetirizine
- cevimeline
- chlophedianol
- chloral hydrate
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- choline salicylate
- cilostazol
- cimetidine
- cinacalcet
- ciprofloxacin
- citalopram
- clemastine
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- cobicistat
- codeine
- conjugated estrogens
- conjugated estrogens topical
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dabigatran
- daclizumab
- dacomitinib
- dalteparin
- danaparoid
- dantrolene
- daridorexant
- darifenacin
- dasatinib
- deferasirox
- defibrotide
- delavirdine
- desipramine
- desirudin
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexlansoprazole
- dexmedetomidine
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- dichlorphenamide
- diclofenac
- dicumarol
- diethylpropion
- difelikefalin
- diflunisal
- dihydroergotamine
- dihydroxyaluminum sodium carbonate
- dimenhydrinate
- diphenhydramine
- dipivefrin ophthalmic
- dipyridamole
- divalproex sodium
- dobutamine
- dolasetron
- donepezil
- dopamine
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drotrecogin alfa
E
- echinacea
- edoxaban
- efavirenz
- eletriptan
- eliglustat
- emapalumab
- enoxacin
- enoxaparin
- entacapone
- ephedrine
- ephedrine nasal
- epinephrine
- epinephrine ophthalmic
- epinephrine topical
- epirubicin
- eplerenone
- epoprostenol
- eptifibatide
- ergotamine
- escitalopram
- eslicarbazepine
- esomeprazole
- estazolam
- estradiol
- estradiol topical
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etodolac
- etranacogene dezaparvovec
- evening primrose
- ezogabine
F
- famotidine
- fedratinib
- felbamate
- fenfluramine
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flecainide
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- flurbiprofen
- fluvoxamine
- fondaparinux
- formoterol
- fosphenytoin
- frovatriptan
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gepirone
- ginkgo
- givosiran
- glofitamab
- glycerol phenylbutyrate
- goldenseal
- golimumab
- granisetron
- grepafloxacin
- guselkumab
H
- halazepam
- halofantrine
- haloperidol
- heparin
- heroin
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyamphetamine ophthalmic
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- ibritumomab
- ibrutinib
- ibuprofen
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- indacaterol
- indapamide
- indomethacin
- infliximab
- inotersen
- interferon beta-1a
- interferon beta-1b
- iobenguane I 123
- iobenguane I 131
- iodine i 131 tositumomab
- ioflupane I 123
- iohexol
- iomeprol
- iopamidol
- isocarboxazid
- isoetharine
- isoniazid
- isoproterenol
K
L
- lacosamide
- lamotrigine
- lansoprazole
- lasmiditan
- leflunomide
- lemborexant
- leniolisib
- lepirudin
- levalbuterol
- levetiracetam
- levmetamfetamine nasal
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lisdexamfetamine
- lithium
- lofexidine
- lomitapide
- lorazepam
- lorcaserin
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium salicylate
- mannitol
- maprotiline
- mavorixafor
- mazindol
- meclizine
- meclofenamate
- mefenamic acid
- melatonin
- meloxicam
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- methadone
- methamphetamine
- methazolamide
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxamine
- methsuximide
- methyclothiazide
- methylene blue
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metyrosine
- mexiletine
- mibefradil
- midazolam
- midodrine
- milnacipran
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nabumetone
- nalbuphine
- nalidixic acid
- naltrexone
- naphazoline nasal
- naphazoline ophthalmic
- naproxen
- naratriptan
- nebivolol
- nefazodone
- nemolizumab
- niclosamide
- nicotine
- nilotinib
- niraparib
- nizatidine
- norepinephrine
- norfloxacin
- nortriptyline
O
- obeticholic acid
- olanzapine
- olaparib
- oliceridine
- olodaterol
- olopatadine nasal
- omeprazole
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- oxamniquine
- oxaprozin
- oxazepam
- oxcarbazepine
- oxycodone
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- ozanimod
P
- pacritinib
- paliperidone
- palonosetron
- panobinostat
- pantoprazole
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentermine
- phenylbutazone
- phenylephrine
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine topical
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pirbuterol
- pirfenidone
- piroxicam
- pitolisant
- plasminogen, human
- plicamycin
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- pramipexole
- prasugrel
- pregabalin
- primaquine
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propiomazine
- propoxyphene
- propranolol
- propylhexedrine nasal
- protein c
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
- rabeprazole
- racepinephrine
- ramelteon
- ramucirumab
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- regorafenib
- remdesivir
- remifentanil
- remimazolam
- reteplase
- rifampin
- rilonacept
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rivaroxaban
- rizatriptan
- rofecoxib
- rolapitant
- ropinirole
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
S
- safinamide
- salmeterol
- salsalate
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- siltuximab
- sodium bicarbonate
- sodium citrate
- sodium salicylate
- sodium thiosalicylate
- sofpironium topical
- solriamfetol
- spironolactone
- st. john's wort
- stiripentol
- streptokinase
- sufentanil
- sulfinpyrazone
- sulindac
- sumatriptan
- suvorexant
T
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- tazemetostat
- tedizolid
- temazepam
- tenecteplase
- terbinafine
- terbutaline
- teriflunomide
- tetrabenazine
- tetrahydrozoline nasal
- tetrahydrozoline ophthalmic
- thalidomide
- thiabendazole
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- ticlopidine
- timolol
- timolol ophthalmic
- tinzaparin
- tirofiban
- tirzepatide
- tizanidine
- tocilizumab
- tolcapone
- tolmetin
- tolterodine
- topiramate
- torsemide
- tositumomab
- tovorafenib
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- treprostinil
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- triprolidine
- tryptophan
- turmeric
U
V
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- varenicline
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vorapaxar
- vortioxetine
W
X
Z
Cymbalta alcohol/food interactions
There are 2 alcohol/food interactions with Cymbalta (duloxetine).
Cymbalta disease interactions
There are 10 disease interactions with Cymbalta (duloxetine) which include:
- liver disease
- renal disease
- depression
- diabetes
- glaucoma
- hypertension
- hyponatremia
- mania
- seizures
- urinary tract obstruction
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- Drug class: serotonin-norepinephrine reuptake inhibitors
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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