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Cymbalta and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Cymbalta (duloxetine).

Moderate

DULoxetine food

Moderate Food Interaction

DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should avoid or limit the use of alcohol while being treated with DULoxetine. Call your doctor immediately if you have fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, dark colored urine, or yellowing of the skin or the whites of your eyes, as these may be symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

SNRI antidepressants - hypertension

Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure. Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension. Blood pressure should be assessed prior to initiating treatment and monitored regularly. The dose should be reduced or discontinued if necessary.

References

  1. "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories PROD (2001):
  2. "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company (2004):
  3. "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories (2008):
  4. "Product Information. Savella (milnacipran)." Forest Pharmaceuticals (2009):
  5. "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals (2013):
View all 5 references

Cymbalta drug interactions

There are 592 drug interactions with Cymbalta (duloxetine).

Cymbalta disease interactions

There are 10 disease interactions with Cymbalta (duloxetine) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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