Diphenhydramine/pseudoephedrine Interactions
There are 573 drugs known to interact with diphenhydramine/pseudoephedrine, along with 14 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 28 are major, 539 are moderate, and 6 are minor.
- View all 573 medications that may interact with diphenhydramine/pseudoephedrine
- View diphenhydramine/pseudoephedrine alcohol/food interactions (2)
- View diphenhydramine/pseudoephedrine disease interactions (14)
Most frequently checked interactions
View interaction reports for diphenhydramine / pseudoephedrine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aller-Tec (cetirizine)
- Ambien (zolpidem)
- Bayer Aspirin Regimen (aspirin)
- Bayer Women's Low Dose Plus Calcium (aspirin / calcium carbonate)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Celebrex (celecoxib)
- Centrum Silver (multivitamin with minerals)
- Cialis (tadalafil)
- Cod Liver Oil (multivitamin)
- Colace (docusate)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Fortesta (testosterone)
- Gas-X (simethicone)
- Gelnique (oxybutynin)
- GenTeal (ocular lubricant ophthalmic)
- Glucosamine & Chondroitin with MSM (chondroitin / glucosamine / methylsulfonylmethane)
- Guaifed Caps (guaifenesin / phenylephrine)
- Lortab (acetaminophen / hydrocodone)
- Lotemax (loteprednol ophthalmic)
- MegaKrill (omega-3 polyunsaturated fatty acids)
- MethylPREDNISolone Dose Pack (methylprednisolone)
- Metoprolol Tartrate (metoprolol)
- Mobic (meloxicam)
- Moderna COVID-19 Vaccine (COVID-19 mRNA (Moderna) vaccine)
- Vitamin D3 (cholecalciferol)
Diphenhydramine/pseudoephedrine alcohol/food interactions
There are 2 alcohol/food interactions with diphenhydramine / pseudoephedrine.
Diphenhydramine/pseudoephedrine disease interactions
There are 14 disease interactions with diphenhydramine / pseudoephedrine which include:
- depression
- cardiovascular disease
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
More about diphenhydramine / pseudoephedrine
- diphenhydramine/pseudoephedrine consumer information
- Compare alternatives
- Reviews (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.