Diphenhydramine/pseudoephedrine Interactions
There are 591 drugs known to interact with diphenhydramine/pseudoephedrine, along with 14 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 36 are major, 547 are moderate, and 8 are minor.
- View all 591 medications that may interact with diphenhydramine/pseudoephedrine
- View diphenhydramine/pseudoephedrine alcohol/food interactions (2)
- View diphenhydramine/pseudoephedrine disease interactions (14)
Most frequently checked interactions
View interaction reports for diphenhydramine / pseudoephedrine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Aller-Tec (cetirizine)
- Ambien (zolpidem)
- Bayer Aspirin Regimen (aspirin)
- Bayer Women's Low Dose Plus Calcium (aspirin / calcium carbonate)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Celebrex (celecoxib)
- Centrum Silver (multivitamin with minerals)
- Cialis (tadalafil)
- Cod Liver Oil (multivitamin)
- Colace (docusate)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Fortesta (testosterone)
- Gas-X (simethicone)
- Gelnique (oxybutynin)
- GenTeal (ocular lubricant ophthalmic)
- Glucosamine & Chondroitin with MSM (chondroitin / glucosamine / methylsulfonylmethane)
- Guaifed Caps (guaifenesin / phenylephrine)
- Iron Sulfate (ferrous sulfate)
- Lortab (acetaminophen / hydrocodone)
- Lotemax (loteprednol ophthalmic)
- Lyrica (pregabalin)
- MegaKrill (omega-3 polyunsaturated fatty acids)
- MethylPREDNISolone Dose Pack (methylprednisolone)
- Metoprolol Tartrate (metoprolol)
- Vitamin D3 (cholecalciferol)
Diphenhydramine/pseudoephedrine alcohol/food interactions
There are 2 alcohol/food interactions with diphenhydramine / pseudoephedrine.
Diphenhydramine/pseudoephedrine disease interactions
There are 14 disease interactions with diphenhydramine / pseudoephedrine which include:
- depression
- cardiovascular disease
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
Report options
More about diphenhydramine / pseudoephedrine
- Compare alternatives
- Reviews (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Ozempic
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Pseudoephedrine
Pseudoephedrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain ...
Sodium chloride nasal
Sodium chloride nasal is used for nasal congestion
Fluticasone nasal
Fluticasone nasal is used for allergic rhinitis, allergies, chronic rhinosinusitis with nasal ...
Promethazine
Promethazine is a phenothiazine and antihistamine used to treat allergies, motion sickness, nausea ...
Triamcinolone nasal
Triamcinolone nasal is used for allergic rhinitis, allergies
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.