Diphenhydramine / Pseudoephedrine Dosage

Usual Adult Dose for Nasal Congestion

2 tablets (25 mg-30 mg) or 2 disintegrating tablet (12.5 mg-30 mg) or 10 mL liquid (12.5 mg-30 mg/5 mL) every 4 to 6 hours as needed. Maximum recommended daily dose is 8 tablets or 40 mL.

-or-

1 tablet (25 mg-60 mg) every 4 to 6 hours as needed. Maximum recommended daily dose is 4 tablets

Usual Adult Dose for Allergic Rhinitis

1 to 2 tablets (25 mg-30 mg) or 2 disintegrating tablets (12.5 mg-30 mg) or 10 mL liquid (12.5 mg-30 mg/5 mL) every 4 to 6 hours as needed. Maximum recommended daily dose is 8 tablets or 40 mL.

-or-

1 tablet (25 mg-60 mg) every 4 to 6 hours as needed. Maximum recommended daily dose is 4 tablets.

Usual Pediatric Dose for Allergic Rhinitis

6 years to 12 years:
5 mL liquid (12.5 mg-30 mg/5 mL) or 1 disintegrating tablet (12.5 mg-30 mg) orally every 4 to 6 hours as needed. Maximum recommended daily dose 20 mL or 4 tablets.

13 years or older:
2 tablets (25 mg-30 mg) or disintegrating tablets (12.5 mg-30 mg) or 10 mL liquid (12.5 mg-30 mg/5 mL) orally every 4 to 6 hours as needed. Maximum recommended daily dose is 8 tablets or 40 mL.
-or-
1 tablet (25 mg-60 mg) every 4 to 6 hours as needed. Maximum recommended daily dose is 4 tablets.

Usual Pediatric Dose for Nasal Congestion

6 years to 12 years:
5 mL liquid (12.5 mg-30 mg/5 mL) or 1 disintegrating tablet (12.5 mg-30 mg) orally every 4 to 6 hours as needed. Maximum recommended daily dose 20 mL or 4 tablets.

13 years or older:
2 tablets (25 mg-30 mg) or disintegrating tablets (12.5 mg-30 mg) or 10 mL liquid (12.5 mg-30 mg/5 mL) orally every 4 to 6 hours as needed. Maximum recommended daily dose is 8 tablets or 40 mL.
-or-
1 tablet (25 mg-60 mg) every 4 to 6 hours as needed. Maximum recommended daily dose is 4 tablets.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer