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Codeine / guaifenesin Drug Interactions

A total of 866 drugs are known to interact with codeine / guaifenesin.

  • 236 major drug interactions
  • 628 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with codeine / guaifenesin.

Check for interactions

Type in a drug name to check for interactions with codeine / guaifenesin.

Most frequently checked interactions

View interaction reports for codeine / guaifenesin and the medicines listed below.

  • Advair Diskus (fluticasone / salmeterol)
  • Aspirin Low Strength (aspirin)
  • Azithromycin Dose Pack (azithromycin)
  • Benadryl (diphenhydramine)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • Cymbalta (duloxetine)
  • Flexeril (cyclobenzaprine)
  • Flonase (fluticasone nasal)
  • guaifenesin (Mucinex, Robafen, Robitussin Chest Congestion, Tussin, Humibid, Tussin Expectorant, Guiatuss, Sorbutuss, Mucinex Maximum Strength, Guaiatussin, Mucus Relief, Diabetic Tussin Mucus Relief, Altarussin, Q-Tussin, Siltussin, Balminil Expectorant, Dristan Chesty Cough Guaiphenesin, Ganidin NR, Fenesin, Scot-Tussin Expectorant, Guaifenesin LA, Humavent LA, Lotussin, Robitussin Mucus + Chest Congestion, Guaifenex G, Benylin E, Mucinex for Kids, Buckley's Chest Congestion, Refenesen Chest Congestion Relief, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Iofen-NF, Humibid Pediatric, Organ-1 NR, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Muco-Fen LA, Liquibid, Muco-Fen 800, Breonesin, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Diabetic Tuss, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Xpect, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Guaifen NR, Liquituss GG, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power)
  • Lasix (furosemide)
  • Mucinex (guaifenesin)
  • Norco (acetaminophen / hydrocodone)
  • ProAir HFA (albuterol)
  • pseudoephedrine (Sudafed Congestion, Sudafed 12-Hour, SudoGest, Entex, Sudafed 24-Hour, Silfedrine, Sudafed Children's Nasal Decongestant, Contac Cold, Suphedrin, Chlor-Trimeton Nasal Decongestant, Nexafed Nasal Decongestant, nasofed, Suphedrine, ElixSure Congestion, Children's Dimetapp Decongestant Infant, Allermed, Novafed, Cenafed, Genaphed, Ridafed, Seudotabs, Sudrine, Superfed, Afrinol, Zephrex-D, Decofed Liquid, Efidac, Decofed, Kid Kare Drops, Myfedrine, Sudodrin, Elixsure Decongestant, Unifed, Drixoral Decongestant Non-Drowsy, SudoGest 12 Hour, 12 Hour Decongestant, 12 Hour Nasal Decongestant)
  • Singulair (montelukast)
  • Symbicort (budesonide / formoterol)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Codeine / guaifenesin alcohol/food interactions

There is 1 alcohol/food interaction with codeine / guaifenesin

Codeine / guaifenesin disease interactions

There are 16 disease interactions with codeine / guaifenesin which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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