Codeine/guaifenesin Interactions
There are 523 drugs known to interact with codeine/guaifenesin, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 124 are major, 396 are moderate, and 3 are minor.
- View all 523 medications that may interact with codeine/guaifenesin
- View codeine/guaifenesin alcohol/food interactions (1)
- View codeine/guaifenesin disease interactions (16)
Most frequently checked interactions
View interaction reports for codeine / guaifenesin and the medicines listed below.
- Advair Diskus (fluticasone / salmeterol)
- Advil (ibuprofen)
- Aleve (naproxen)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Azithromycin Dose Pack (azithromycin)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Metoprolol Tartrate (metoprolol)
- Mucinex (guaifenesin)
- Norco (acetaminophen / hydrocodone)
- Paxlovid (nirmatrelvir / ritonavir)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Codeine/guaifenesin alcohol/food interactions
There is 1 alcohol/food interaction with codeine / guaifenesin.
Codeine/guaifenesin disease interactions
There are 16 disease interactions with codeine / guaifenesin which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
Report options
More about codeine / guaifenesin
- codeine/guaifenesin consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (87)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Mucinex
Mucinex (guaifenesin) is used to relieve the symptoms of cough and loosen mucus in the chest ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Norco
Norco (acetaminophen and hydrocodone) is used to relieve moderate to severe pain. Includes Norco ...
Dilaudid
Dilaudid (hydromorphone) is a narcotic pain reliever used to treat moderate to severe pain ...
Acetaminophen/hydrocodone
The combination of hydrocodone and acetaminophen is used to relieve moderate to severe pain ...
Codeine
Codeine is a opioid pain medicine used to treat mild to moderate pain. Includes codeine side ...
Hydromorphone
Hydromorphone systemic is used for anesthetic adjunct, chronic pain, cough, pain
Dextromethorphan
Dextromethorphan is a cough suppressant used to treat coughing. Learn about side effects ...
Guaifenesin
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat. Includes ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
