Codeine/guaifenesin Interactions
There are 524 drugs known to interact with codeine/guaifenesin, along with 16 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 125 are major, 396 are moderate, and 3 are minor.
- View all 524 medications that may interact with codeine/guaifenesin
- View codeine/guaifenesin alcohol/food interactions (1)
- View codeine/guaifenesin disease interactions (16)
Most frequently checked interactions
View interaction reports for codeine / guaifenesin and the medicines listed below.
- Advair Diskus (fluticasone / salmeterol)
- Aleve (naproxen)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Augmentin (amoxicillin / clavulanate)
- Azithromycin Dose Pack (azithromycin)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Metoprolol Tartrate (metoprolol)
- Mucinex (guaifenesin)
- Norco (acetaminophen / hydrocodone)
- Paxlovid (nirmatrelvir / ritonavir)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Symbicort (budesonide / formoterol)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Codeine/guaifenesin alcohol/food interactions
There is 1 alcohol/food interaction with codeine / guaifenesin.
Codeine/guaifenesin disease interactions
There are 16 disease interactions with codeine / guaifenesin which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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More about codeine / guaifenesin
- codeine/guaifenesin consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (87)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
