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Codeine / Guaifenesin Dosage

Medically reviewed by Last updated on Oct 16, 2023.

Applies to the following strengths: 10 mg-100 mg/5 mL; 10 mg-300 mg; 2.5 mg-75 mg/5 mL; 10 mg-300 mg/5 mL; 10 mg-200 mg/5 mL; 7.5 mg-225 mg/5 mL; 9 mg-200 mg; 6.3 mg-100 mg/5 mL; 10 mg-400 mg; 20 mg-400 mg; 8 mg-200 mg/5 mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Cough

1 dose orally every 4 to 6 hours as needed

Maximum dose should not exceed maximum dose of either of the single ingredient doses


Uses: Temporary relief of coughs due to minor throat and bronchial irritations as may occur with the common cold or inhaled irritants; helps loosen phlegm and thin bronchial secretions to make cough more productive.

Renal Dose Adjustments

Dose adjustments not recommended

Liver Dose Adjustments

Dose adjustments not recommended


The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for all opioids intended for outpatient use. The new FDA Opioid Analgesic REMS is a designed to assist in communicating the serious risks of opioid pain medications to patients and health care professionals. It includes a medication guide and elements to assure safe use. For additional information:

The US FDA recommends against use of codeine-containing cough and cold medications in patients less than 18 years because it has been determined that the risks outweigh benefits.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule V


Data not available

Other Comments

Administration advice:

Storage requirements:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.