Wellbutrin XL Drug Interactions
Currently displaying a list of 559 drugs known to interact with Wellbutrin XL (bupropion).
- 218 major drug interactions
- 336 moderate drug interactions
- 5 minor drug interactions
Medications known to interact with Wellbutrin XL
Note: Showing generic names only.
A
- abametapir topical
- acebutolol
- acetaminophen
- acetylcarbromal
- adalimumab
- albendazole
- albuterol
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- alosetron
- alpelisib
- alprazolam
- amantadine
- amifampridine
- amiloride
- aminophylline
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- anagrelide
- anakinra
- anisindione
- apalutamide
- apomorphine
- aprepitant
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atomoxetine
- axitinib
- azilsartan medoxomil
B
- bedaquiline
- benazepril
- bendamustine
- bendroflumethiazide
- benzgalantamine
- benzphetamine
- benzthiazide
- bepridil
- betamethasone
- betaxolol
- bethanechol
- bimekizumab
- bisoprolol
- bitolterol
- black cohosh
- blinatumomab
- bortezomib
- brentuximab
- brexanolone
- brexpiprazole
- brodalumab
- bromocriptine
- bumetanide
- buprenorphine
- butabarbital
- butalbital
- butorphanol
C
- cabergoline
- caffeine
- calaspargase pegol
- canakinumab
- candesartan
- cannabidiol
- captopril
- carbamazepine
- cariprazine
- carteolol
- carvedilol
- cefiderocol
- cenobamate
- cetirizine
- cevimeline
- chloral hydrate
- chlordiazepoxide
- chlormezanone
- chloroquine
- chlorothiazide
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- cimetidine
- cinacalcet
- cinoxacin
- ciprofloxacin
- citalopram
- clevidipine
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- cocaine nasal
- cocaine topical
- codeine
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
- cyclobenzaprine
- cyclophosphamide
- cycloserine
- cyclosporine
D
- dabrafenib
- daclizumab
- dalfampridine
- darifenacin
- deflazacort
- delafloxacin
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexfenfluramine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicumarol
- diethylpropion
- digoxin
- dihydroergotamine
- diltiazem
- diphenhydramine
- dipivefrin ophthalmic
- divalproex sodium
- dobutamine
- dolasetron
- donepezil
- dopamine
- doxapram
- doxazosin
- doxepin
- doxepin topical
- dronabinol
- droperidol
- droxidopa
- duloxetine
E
- efavirenz
- eliglustat
- eluxadoline
- emapalumab
- enalapril
- enalaprilat
- enoxacin
- enzalutamide
- epcoritamab
- ephedrine
- ephedrine nasal
- epinephrine
- epinephrine ophthalmic
- epinephrine topical
- epirubicin
- eplerenone
- eprosartan
- ergonovine
- ergotamine
- erlotinib
- ertapenem
- escitalopram
- esmolol
- estazolam
- estradiol
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- etranacogene dezaparvovec
- evening primrose
F
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flecainide
- flibanserin
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- flutamide
- fluvoxamine
- formoterol
- foscarnet
- fosinopril
- fosphenytoin
- furazolidone
- furosemide
G
- galantamine
- gatifloxacin
- gefitinib
- gemifloxacin
- ginkgo
- glofitamab
- golimumab
- granisetron
- grepafloxacin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydrocortisone
- hydroflumethiazide
- hydromorphone
- hydroxyamphetamine ophthalmic
- hydroxychloroquine
- hydroxyprogesterone
I
- idelalisib
- ifosfamide
- iloperidone
- imipramine
- indacaterol
- indapamide
- infliximab
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfa-n3
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- iobenguane I 123
- iobenguane I 131
- ioflupane I 123
- iohexol
- iomeprol
- iopamidol
- irbesartan
- isavuconazonium
- isocarboxazid
- isoetharine
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- istradefylline
- ivosidenib
K
L
- labetalol
- landiolol
- larotrectinib
- lasmiditan
- leflunomide
- lemborexant
- levalbuterol
- levamlodipine
- levmetamfetamine nasal
- levobupivacaine
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lomefloxacin
- lomitapide
- lorazepam
- lorcaserin
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- maprotiline
- mazindol
- mefloquine
- melatonin
- meperidine
- mephentermine
- mephobarbital
- meprobamate
- meropenem
- mesoridazine
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methdilazine
- methotrexate
- methotrimeprazine
- methoxamine
- methyclothiazide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- mexiletine
- mibefradil
- midazolam
- midodrine
- mifepristone
- milnacipran
- minoxidil
- mipomersen
- mirtazapine
- mitapivat
- mitotane
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
- moxifloxacin
- muromonab-cd3
N
- nabumetone
- nadolol
- nalbuphine
- nalidixic acid
- naltrexone
- naphazoline nasal
- naphazoline ophthalmic
- naproxen
- nebivolol
- nefazodone
- nelarabine
- nemolizumab
- neostigmine
- nevirapine
- nicardipine
- nicotine
- nifedipine
- nilotinib
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- norepinephrine
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olodaterol
- olopatadine nasal
- ondansetron
- opium
- orphenadrine
- oxamniquine
- oxazepam
- oxtriphylline
- oxycodone
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- ozanimod
P
- paliperidone
- palonosetron
- papaverine
- paraldehyde
- paroxetine
- pegaspargase
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pemoline
- penbutolol
- pentazocine
- pentobarbital
- pentoxifylline
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phendimetrazine
- phenelzine
- phenobarbital
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine topical
- phenylpropanolamine
- phenytoin
- physostigmine
- pimozide
- pindolol
- pioglitazone
- piperazine
- pirbuterol
- pirfenidone
- pitolisant
- polyethylene glycol 3350 with electrolytes
- polythiazide
- pramipexole
- prasugrel
- prazosin
- prednisolone
- prednisone
- primidone
- procarbazine
- prochlorperazine
- promazine
- promethazine
- propafenone
- propiomazine
- propoxyphene
- propranolol
- propylhexedrine nasal
- protriptyline
- pseudoephedrine
Q
R
- racepinephrine
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- reserpine
- rifampin
- rilonacept
- riluzole
- rimantadine
- risperidone
- ritodrine
- ritonavir
- rivastigmine
- roflumilast
- ropinirole
- ropivacaine
- rotigotine
- rufinamide
S
- safinamide
- salmeterol
- sarilumab
- satralizumab
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- silodosin
- siltuximab
- sodium oxybate
- sofpironium topical
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- stiripentol
- sufentanil
T
- tacrine
- tamoxifen
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- teclistamab
- tedizolid
- telmisartan
- telotristat
- temazepam
- terazosin
- terbutaline
- teriflunomide
- tetrabenazine
- tetrahydrozoline nasal
- tetrahydrozoline ophthalmic
- theophylline
- thiabendazole
- thiethylperazine
- thioguanine
- thioridazine
- thiotepa
- thiothixene
- ticlopidine
- timolol
- timolol ophthalmic
- tizanidine
- tocilizumab
- tolterodine
- torsemide
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamcinolone
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trimeprazine
- trimethaphan camsylate
- trimipramine
- trovafloxacin
U
V
- vadadustat
- valbenazine
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- venlafaxine
- verapamil
- vilazodone
- vortioxetine
W
X
Z
Wellbutrin XL alcohol/food interactions
There is 1 alcohol/food interaction with Wellbutrin XL (bupropion).
Wellbutrin XL disease interactions
There are 7 disease interactions with Wellbutrin XL (bupropion) which include:
- suicidality
- seizure disorders
- angle closure glaucoma
- liver disease
- mixed/manic episode
- renal dysfunction
- weight loss
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- Drug class: miscellaneous antidepressants
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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