Acetaminophen/caffeine Drug Interactions
Currently displaying a list of 247 drugs known to interact with acetaminophen / caffeine.
- 13 major drug interactions
- 188 moderate drug interactions
- 46 minor drug interactions
Medications known to interact with acetaminophen/caffeine
Note: Showing generic names only.
A
- abametapir topical
- adenosine
- albuterol
- alosetron
- aminophylline
- amobarbital
- amphetamine
- anagrelide
- anisindione
- apalutamide
- arformoterol
- armodafinil
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atazanavir
- atezolizumab
- atomoxetine
- atropine
- avelumab
B
- bedaquiline
- belladonna
- bendamustine
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benztropine
- biperiden
- bitolterol
- black cohosh
- brentuximab
- bupivacaine
- bupivacaine liposome
- bupropion
- busulfan
- butabarbital
- butalbital
C
- calaspargase pegol
- cannabidiol
- capmatinib
- carbamazepine
- cemiplimab
- ceritinib
- charcoal
- chloroprocaine
- chloroprocaine ophthalmic
- cholestyramine
- cimetidine
- ciprofloxacin
- clidinium
- clofarabine
- clozapine
- cocaine nasal
- cocaine topical
- cosibelimab
- cycloserine
D
- daclizumab
- darifenacin
- deferasirox
- dexmethylphenidate
- dextroamphetamine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- diflunisal
- dipyridamole
- disulfiram
- dobutamine
- dopamine
- dostarlimab
- doxapram
- duloxetine
- durvalumab
E
- echinacea
- efavirenz
- encorafenib
- enoxacin
- ephedrine
- epinephrine
- epirubicin
- esketamine
- ethanol
- ethinyl estradiol
- ethotoin
- etidocaine
- etranacogene dezaparvovec
F
- fenfluramine
- fenofibrate
- fenoldopam
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- flavoxate
- fluvoxamine
- formoterol
- fosphenytoin
G
H
I
- idelalisib
- imatinib
- indacaterol
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- isoetharine
- isoniazid
- isoproterenol
K
L
- leflunomide
- leniolisib
- levalbuterol
- levobupivacaine
- levoketoconazole
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- liraglutide
- lisdexamfetamine
- lithium
- lomitapide
- lorlatinib
M
- ma huang
- mavorixafor
- mazindol
- melatonin
- mepenzolate
- mephentermine
- mephenytoin
- mephobarbital
- mepivacaine
- metaproterenol
- metaraminol
- methamphetamine
- methohexital
- methotrexate
- methoxamine
- methscopolamine
- methylphenidate
- metoclopramide
- mibefradil
- mipomersen
- modafinil
N
O
- obeticholic acid
- olaparib
- olodaterol
- olutasidenib
- omaveloxolone
- osilodrostat
- osimertinib
- ospemifene
- oxazepam
- oxybutynin
P
- pacritinib
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentobarbital
- pexidartinib
- phendimetrazine
- phenobarbital
- phentermine
- phenylephrine
- phenylpropanolamine
- phenytoin
- pimozide
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- pralsetinib
- pramoxine topical
- primidone
- probenecid
- procaine
- procyclidine
- propantheline
- proparacaine ophthalmic
- propranolol
- pseudoephedrine
R
- racepinephrine
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- rasagiline
- regadenoson
- remdesivir
- retifanlimab
- rifampin
- riluzole
- ritlecitinib
- ritodrine
- ropinirole
- ropivacaine
- rucaparib
S
T
- tafamidis
- terbinafine
- terbutaline
- teriflunomide
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- theophylline
- thiabendazole
- thioguanine
- thiopental
- tirzepatide
- tislelizumab
- tizanidine
- tolterodine
- topotecan
- toripalimab
- trabectedin
- tremelimumab
- trihexyphenidyl
- trospium
- trovafloxacin
V
W
Z
Acetaminophen/caffeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / caffeine.
Acetaminophen/caffeine disease interactions
There are 12 disease interactions with acetaminophen / caffeine which include:
- alcoholism
- liver disease
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
Report options
QR code containing a link to this page
More about acetaminophen / caffeine
- acetaminophen/caffeine consumer information
- Check interactions
- Compare alternatives
- Reviews (8)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
