Acetaminophen/caffeine Interactions
There are 247 drugs known to interact with acetaminophen/caffeine, along with 12 disease interactions, and 6 alcohol/food interactions. Of the total drug interactions, 13 are major, 188 are moderate, and 46 are minor.
- View all 247 medications that may interact with acetaminophen/caffeine
- View acetaminophen/caffeine alcohol/food interactions (6)
- View acetaminophen/caffeine disease interactions (12)
Most frequently checked interactions
View interaction reports for acetaminophen / caffeine and the medicines listed below.
- Adderall XR (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Aleve (naproxen)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- Calcium 600 D (calcium / vitamin d)
- Coenzyme Q10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Imodium (loperamide)
- Iron Sulfate (ferrous sulfate)
- Lexapro (escitalopram)
- Metoprolol Succinate ER (metoprolol)
- Norco (acetaminophen / hydrocodone)
- Paracetamol (acetaminophen)
- Pepto-Bismol (bismuth subsalicylate)
- Pfizer-BioNTech COVID-19 Vaccine (COVID-19 mRNA (Pfizer) vaccine)
- Symbicort (budesonide / formoterol)
- Topamax (topiramate)
- Tylenol (acetaminophen)
- Tylenol Extra Strength (acetaminophen)
- Vitamin B Complex 100 (multivitamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin B6 (pyridoxine)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Zanaflex (tizanidine)
- Zyrtec (cetirizine)
Acetaminophen/caffeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / caffeine.
Acetaminophen/caffeine disease interactions
There are 12 disease interactions with acetaminophen / caffeine which include:
- alcoholism
- liver disease
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
Report options
More about acetaminophen / caffeine
- acetaminophen/caffeine consumer information
- Compare alternatives
- Reviews (8)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Cyclobenzaprine
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Amoxicillin
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Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Ibuprofen
Ibuprofen (Advil, Motrin) treats minor aches and pains caused by the common cold, headaches ...
Paracetamol
Paracetamol (Panadol, Calpol, Alvedon) is a widely used over-the-counter painkiller and fever ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
