Skip to main content

Sufentanil Dosage

Applies to the following strengths: 50 mcg/mL; 30 mcg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

ADJUNCT TO GENERAL ANESTHESIA: Total Dosage Requirement: 1 mcg/kg/hr or less (expected surgical time)

Total Dosage (Incremental or Infusion): 1 to 2 mcg/kg IV
Maintenance dose: 10 to 25 mcg IV as needed when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia
Total Dosage (Incremental or Infusion): 2 to 8 mcg/kg IV
Maintenance dose: 10 to 50 mcg IV when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia

INDUCTION AND MAINTENANCE OF ANESTHESIA:
As primary anesthetic agent: 8 mcg/kg or greater
Total Dosage for procedure should not exceed 30 mcg/kg (Incremental or Infusion)

Comments:

Uses: As a primary anesthetic or an analgesic adjunct for patients intubated and ventilated.

Usual Adult Dose for Labor Pain

10 to 15 mcg with 10 mL of bupivacaine 0.125% with or without epinephrine


Comments:

Use: As an analgesic (in combination with bupivacaine) during labor and vaginal delivery.

Usual Adult Dose for Pain

30 mcg sublingually once; may repeat dose as needing allowing a minimum of 1 hour between doses
Maximum dose: 360 mcg (12 tablets) in 24 hours
Maximum duration: 72 hours

Comments:


Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Usual Pediatric Dose for Anesthesia

Doses should be individualized and titrated to the desired effect according to body weight, physical status, underlying pathological condition, use of other drugs, and type and duration of surgical procedure, and anesthesia:

ADJUNCT TO GENERAL ANESTHESIA: Total Dosage Requirement: 1 mcg/kg/hr or less (expected surgical time)

Total Dosage (Incremental or Infusion): 1 to 2 mcg/kg IV
Maintenance dose: 10 to 25 mcg IV as needed when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia
Total Dosage (Incremental or Infusion): 2 to 8 mcg/kg IV
Maintenance dose: 10 to 50 mcg IV when movement and/or changes in vital signs indicate surgical stress or lightening of analgesia

INDUCTION AND MAINTENANCE OF ANESTHESIA:
As primary anesthetic agent: 8 mcg/kg or greater
Total Dosage for procedure should not exceed 30 mcg/kg (Incremental or Infusion)

Cardiovascular Surgery:
Less than 12 years: 10 to 25 mcg/kg IV (administered with 100% oxygen)

Comments:


Uses: As a primary anesthetic or an analgesic adjunct for patients intubated and ventilated.

Renal Dose Adjustments

Use with caution, dosage adjustments may be required; however, no specific guidelines have been suggested.

Liver Dose Adjustments

Use with caution, dosage adjustments may be required; however, no specific guidelines have been suggested.

Dose Adjustments

Elderly: Use caution generally starting at the low end of the dosing range and titrate slowly; monitor closely for signs of CNS and respiratory depression

Concomitant Use or Discontinuation of CYP450 3A4 Inhibitors or Inducers:

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for Dsuvia(R). It includes elements to assure safe use and an implementation system. For additional information: www.accessdata.fda.gov/scripts/cder/rems/index.cfm

US BOXED WARNING: SUBLINGUAL TABLET


US BOXED WARNING: INJECTION

CONTRAINDICATIONS:

Safety and efficacy of sublingual tablets have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:
IV: Administer via slow injection or infusion

Epidural:


Sublingual Tablet:

Storage requirements:
Ampules: Protect from light

Reconstitution/preparation techniques: Consult Manufacturer Package Insert
Epidural use: Mix with bupivacaine prior to administration
Sublingual use: Administer with Single-Dose-Applicator (SDA); SDA should be disposed in biohazard waste after administration

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.