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Sufentanil Side Effects

For the Consumer

Applies to sufentanil: injection solution

Along with its needed effects, sufentanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sufentanil:

Incidence not known
  • Agitation
  • blurred vision
  • confusion
  • cough
  • darkening of the skin
  • diarrhea
  • difficult or troubled breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast heartbeat
  • fever
  • hives, itching, or skin rash
  • irregular, fast or slow, or shallow breathing
  • loss of appetite
  • mental depression
  • muscle stiffness
  • nausea
  • overactive reflexes
  • pale or blue lips, fingernails, or skin
  • poor coordination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • restlessness
  • shivering
  • sweating
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • trembling or shaking
  • twitching
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to sufentanil: compounding powder, injectable solution

General

The most commonly reported adverse events have been apnea, rigidity, and bradycardia.[Ref]

Respiratory

Common (1% to 10%): Respiratory depression
Uncommon (0.1% to 1%): Apnea
Frequency not reported: Respiratory arrest[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity
Postmarketing reports: Anaphylaxis[Ref]

Cardiovascular

Common (1% to 10%): Increased heart rate, increased blood pressure, decreased blood pressure
Uncommon (0.1% to 1%): Decreased heart rate
Rare (0.01% to 0.1%): Bradycardia
Frequency not reported: Severe bradycardia, severe hypotension including orthostatic hypotension, syncope[Ref]

Musculoskeletal

Common (1% to 10%): Involuntary muscle spasms, muscle twitching
Frequency not reported: Muscle rigidity, muscle movement[Ref]

Gastrointestinal

Very common (10% or more): Nausea, vomiting
Common (1% to 10%): Constipation, dyspepsia
Uncommon (0.1% to 1%): Dry mouth

Opioids:
Frequency not reported: increase in serum amylase[Ref]

Psychiatric

Common (1% to 10%): Confusional state
Uncommon (0.1% to 1%): Apathy, nervousness
Frequency not reported: Addiction, abuse, misuse[Ref]

Nervous system

Cases of serotonin syndrome have been reported during concomitant use of opioids with serotonergic drugs.[Ref]

Common (1% to 10%): Dizziness, headache, sedation
Uncommon (0.1% to 1%): Somnolence, paresthesia, ataxia, dystonia, hyperreflexia
Frequency not reported: Seizures, coma

Opioids:
Postmarketing reports: Serotonin syndrome[Ref]

Dermatologic

Very common (10% or more): Pruritus (up to 25%)
Uncommon (0.1% to 1%): Hyperhidrosis, rash, dry skin
Frequency not reported: Erythema[Ref]

Genitourinary

Common (1% to 10%): Urinary retention[Ref]

Ocular

Uncommon (0.1% to 1%): Vision disturbances
Frequency not reported: Miosis[Ref]

Other

Very common (10% or more): Pyrexia
Uncommon (0.1% to 1%): Chills, asthenia
Frequency not reported: Drug withdrawal syndrome[Ref]

Endocrine

Cases of adrenal insufficiency have been reported with opioid use of greater than 1-month duration. Cases of androgen deficiency have occurred with chronic opioid use.[Ref]

Opioids:
Postmarketing reports: Adrenal insufficiency, androgen deficiency[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. SUFentanil Citrate (SUFentanil)." Akorn Inc, Buffalo Grove, IL.

Some side effects of sufentanil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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