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Nalbuphine Dosage

Applies to the following strength(s): 10 mg/mL ; 20 mg/mL

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Pain

10 mg/70 kg administered IV, IM, or subcutaneous every 3 to 6 hours as needed.
Maximum single dose: 20 mg
Maximum daily dose: 160 mg

Usual Adult Dose for Anesthesia

Supplement to balanced anesthesia:
Induction dose: 0.3 to 3 mg/kg IV over 10 to 15 min.
Maintenance dose: 0.25 to 0.5 mg/kg IV once. May repeat as necessary.

Usual Pediatric Dose for Pain

The safety and efficacy of nalbuphine in patients <18 years has not been established. However, the use of nalbuphine may be appropriate in some situations.

>= 1 year to 18 years:
0.1 to 0.2 mg/kg IM, IV, subcutaneous every 3 to 4 hours.
Maximum single dose: 20 mg
Maximum daily dose: 160 mg

Renal Dose Adjustments

CrCl <80 mL/min: lower dose and use with caution.

Liver Dose Adjustments

Lower the dose and use with caution in patients with liver dysfunction.


Because of the possibility of respiratory depression, equipment and personnel necessary for resuscitation should be immediately available when nalbuphine is administered.

Use with caution in patients with sulfite sensitivity, head trauma, increased intracranial pressure, decreased hepatic or renal function, history of drug dependence, recent history of myocardial infarction and patients undergoing biliary tract surgery.

Patients who have been taking narcotics chronically may experience withdrawal symptoms when administered nalbuphine. These symptoms can be controlled by the administration of small increments of morphine to response.

At the usual adult dose nalbuphine can cause respiratory depression approximately equal to that caused by similar doses of morphine. However, respiratory depression is not appreciably increased with higher doses of nalbuphine.

Respiratory depression caused by nalbuphine can be reversed by naloxone if necessary.

Nalbuphine may impair the mental abilities necessary to perform potentially hazardous tasks such as driving or operating machinery.


Data not available