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Levorphanol Dosage

Medically reviewed on December 12, 2017.

Applies to the following strengths: 2 mg; 2 mg/mL

Usual Adult Dose for Pain

As First Opioid Analgesic:
Initial dose: 1 to 2 mg orally every 6 to 8 hours as needed for pain
-May increase dose up to 3 mg orally every 6 to 8 hours as needed; if around the clock dosing is used, allow 72 hours for patient to reach a new steady-state before dose adjustment
Maximum doses: Higher doses may be appropriate in opioid tolerant patients

CONVERSION from other Opioids:
-Due to inter-patient variability, a conservative approach is advised
-Levorphanol is 4 to 8 times as potent as morphine and has a longer half-life
-May consider initiating levorphanol at 1/15 to 1/12 the total daily dose of oral morphine and adjust to clinical response
-Allow 72 hours for patient to reach a new steady-state before dose adjustment

Comments:
-Doses should be adjusted according to the severity of the pain, age, weight, and physical status, underlying disease, and use of concomitant medications.
-Monitor closely for respiratory depression especially on initiation and with each dose increase.
-Because of the risks of addiction, abuse, and misuse, even at recommended doses, this drug should be reserved for use in patients for whom alternative treatment options have not or are not expected to be tolerated or have not or are not expected to provide adequate analgesia.

Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Elderly:
-Use caution when selecting dose, generally starting at the low end of the dosing range; the dose should be reduced by 50% or more in the infirm elderly patient.
-Titrate slowly and monitor closely for signs of CNS and respiratory depression.
-This drug is substantially renally excreted; consider monitoring renal function in elderly patients.

Concomitant use of Respiratory Depressant Agents:
-Initial dose should be reduced by approximately 50% or more when given with another drug affecting respiration

Discontinuation in Physically Dependent Patients:
-Taper dose gradually by 25% to 50% every 2 to 4 days
-If signs and symptoms of withdrawal appear, may raise the dose to the previous level and taper more slowly (either by increasing the interval between doses, decreasing the dose, or both)
-Do not abruptly discontinue in the physically-dependent patient

Precautions

US BOXED WARNINGS:
-ADDICTION, ABUSE, AND MISUSE: This drug exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing this drug and monitor all patients regularly for the development of these behaviors or conditions.
-LIFE-THREATENING RESPIRATORY DEPRESSION: Serious, life-threatening, or fatal respiratory depression may occur with use. Monitor for respiratory depression, especially during initiation of therapy or following a dose increase.
-ACCIDENTAL INGESTION of even one dose, especially by children, can result in a fatal overdose of levorphanol.
-NEONATAL OPIOID WITHDRAWAL SYNDROME: Prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.
-RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS: Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant use for patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required, and follow patients for signs and symptoms of respiratory depression.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally with or without food; taking with food may alleviate gastrointestinal discomfort

General:
-Due to the risk of addiction, abuse, and misuse with opioids, even at recommended doses, this drug is for use in patients for whom alternative treatment options (non-opioid analgesics) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
-For patients receiving other opioid analgesics and switching to this drug, it is safer to underestimate a patient's 24-hour oral requirement and provide rescue medication than overestimate and manage an adverse reaction; there is substantial inter-patient variation in the relative potency of different opioid drugs that conversion tables are not able to capture.
-During chronic therapy, periodically reassess the continued need for opioid analgesics.

Monitoring:
-Cardiovascular: Monitor for signs of hypotension upon initiating therapy and following dose increases, especially those whose blood pressure is compromised
-Respiratory: Monitor for respiratory depression, especially within the first 24 to 72 hours of initiation and with dose increases.
-Gastrointestinal: Monitor for constipation and decreased bowel motility in post-operative patients.
-General: Monitor routinely for maintenance of pain control and incidence of adverse reactions.
-Psychiatric: Patients should be monitored for the development of addiction, abuse, or misuse.

Patient advice:
-Advise patients to store this drug safely out of the sight and reach of children; accidental use by a child is a medical emergency and can result in death.
-Patients should understand that this drug, even when taken as recommended can result in addiction, abuse, and misuse; instruct patients not to share their drug with others and protect their drug from theft or misuse.
-Patients should understand the risks of life-threatening respiratory depression, and be informed as to when this risk is greatest; patients should be advised to avoid alcoholic beverages, or respiratory depressant medications while on treatment.
-This drug may cause drowsiness, dizziness, or impair thinking or motor skills; patients should avoid driving or operating machinery during therapy.
-Women of child bearing potential should understand that prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome and that prompt recognition and treatment will be necessary.
-Patients should be instructed in proper disposal.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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