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Levorphanol Pregnancy and Breastfeeding Warnings

Levorphanol is also known as: Levo-Dromoran

Levorphanol Pregnancy Warnings

Levorphanol has been assigned to pregnancy category C by the FDA. Levorphanol has been shown to be teratogenic in mice when given at a single oral dose of 25 mg/kg. Detailed information about the use of levorphanol in pregnancy is not available. Withdrawal symptoms have been reported in neonates whose mothers took other narcotic analgesics during pregnancy. The manufacturer warns that levorphanol should only be given in pregnancy when benefit outweighs risk.

See references

Levorphanol Breastfeeding Warnings

There are no data on the excretion of levorphanol into human milk. Other narcotic analgesics are excreted into human milk in small amounts. Because of the potential for serious adverse reactions from levorphanol in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Levo-Dromoran (levorphanol)." Roche Laboratories, Nutley, NJ.
  2. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  3. Rementeria JL, Nunag NN "Narcotic withdrawal in pregnancy: stillbirth incidence with a case report." Am J Obstet Gynecol 116 (1973): 1152-6
  4. Zelson C, Lee SJ, Casalino M "Neonatal narcotic addiction: comparative effects of maternal intake of heroin and methadone." N Engl J Med 289 (1973): 1216-20

References for breastfeeding information

  1. Anderson PO "Drug use during breast-feeding." Clin Pharm 10 (1991): 594-623

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