Generic name: levetiracetam 500mg
Dosage form: tablet, film coated, extended release
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KEPPRA XR is administered once daily.
Initiate treatment with a dose of 1000 mg once daily. The once daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg/day.
Dosage Adjustment in Adult Patients with Renal Impairment
KEPPRA XR dosing must be individualized according to the patient's renal function status. Recommended dosage adjustments for adults are shown in Table 1. In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated. To do this, an estimate of the patient's creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:
|CLcr=||[140-age (years)] × weight (kg)||(× 0.85 for female patients)|
|72 × serum creatinine (mg/dL)|
Then CLcr is adjusted for body surface area (BSA) as follows:
|CLcr (mL/min/1.73m2)=||CLcr (mL/min)||× 1.73|
|BSA subject (m2)|
|Normal||> 80||1000 to 3000||Every 24 hours|
|Mild||50 – 80||1000 to 2000||Every 24 hours|
|Moderate||30 – 50||500 to 1500||Every 24 hours|
|Severe||< 30||500 to 1000||Every 24 hours|