Jylamvo Dosage
Generic name: METHOTREXATE 2mg in 1mL
Dosage form: oral solution
Medically reviewed by Drugs.com. Last updated on Apr 28, 2025.
Important Dosage and Safety Information
Verify pregnancy status in females of reproductive potential before starting JYLAMVO.
Instruct patients and caregivers on how to measure and administer the recommended dosage using the copackaged syringe and bottle adaptor as directed, because medication errors have led to deaths.
Ensure patients and caregivers understand the instructions provided in the Patient Information on proper dosing of JYLAMVO based on volume (mL) utilizing the copackaged syringe before use.
Advise patients and caregivers to only use the copackaged syringe to measure JYLAMVO and that a teaspoon is not an appropriate measuring device. The dosing syringe utilizes mL as the unit of measure; ensure that the correct dose expressed in volume (mL) is prescribed. JYLAMVO contains 2 mg of methotrexate in each mL of solution.
JYLAMVO is intended for oral use only. When switching the patient’s dosing regimen from a methotrexate product for oral administration to a methotrexate product for intravenous, intramuscular, or subcutaneous administration, an alternative dosing regimen may be necessary due to potential differences in bioavailability.
JYLAMVO is a hazardous drug. Follow applicable special handling and disposal procedures1.
Recommended Dosage for Neoplastic Diseases
Acute Lymphoblastic Leukemia
The recommended starting dosage of JYLAMVO is 20 mg/m2 orally once weekly, as part of a combination chemotherapy maintenance regimen. After initiating JYLAMVO, periodically monitor absolute neutrophil count (ANC) and platelet count and adjust the dose to maintain ANC at a desirable level and for excessive myelosuppression.
Mycosis Fungoides
The recommended dosage of JYLAMVO is 25 mg to 75 mg orally once weekly when administered as a single agent or 10 mg/m2 orally twice weekly as part of a combination chemotherapy regimen.
Relapsed or Refractory Non-Hodgkin Lymphomas
The recommended dosage of JYLAMVO is 2.5 mg orally 2 to 4 times per week (maximum 10 mg per week) as part of a metronomic combination chemotherapy regimen.
Recommended Dosage for Rheumatoid Arthritis
The recommended starting dosage of JYLAMVO is 7.5 mg orally once weekly with escalation to achieve optimal response. Dosages of more than 20 mg once weekly result in an increased risk of serious adverse reactions, including myelosuppression. When responses are observed, the majority occur between 3 and 6 weeks from initiation of treatment; however, responses have occurred up to 12 weeks after treatment initiation.
Administer folic acid or folinic acid to reduce the risk of methotrexate adverse reactions.
2.4 Recommended Dosage for Polyarticular Juvenile Idiopathic Arthritis
The recommended starting dose of JYLAMVO is 10 mg/m2 orally once weekly with escalation to achieve optimal response. Dosages of more than 30 mg/m2once weekly result in an increased risk of serious adverse reactions, including myelosuppression. When responses are observed, the majority occurred between 3 and 6 weeks from initiation of treatment; however, responses have occurred up to 12 weeks after treatment initiation.
Administer folic acid or folinic acid to reduce the risk of methotrexate adverse reactions.
Recommended Dosage for Psoriasis
The recommended dosage of JYLAMVO is 10 mg to 25 mg orally once weekly until an adequate response is achieved. Adjust the dose gradually to achieve optimal clinical response; do not exceed a dose of 30 mg per week. Once optimal clinical response has been achieved, reduce the dosage to the lowest possible dosing regimen.
Administer folic acid or folinic acid supplementation to reduce the risk of methotrexate adverse reactions.
Dosage Modifications for Adverse Reactions
Discontinue JYLAMVO for:
- Anaphylaxis or other severe hypersensitivity reactions
- Lymphoproliferative disease
Withhold, dose reduce or discontinue JYLAMVO as appropriate for:
- Myelosuppression
Withhold or discontinue JYLAMVO as appropriate for:
- Severe gastrointestinal toxicity
- Hepatotoxicity
- Pulmonary toxicity
- Severe dermatologic reactions
- Severe renal toxicity
- Serious infections
- Neurotoxicity
Frequently asked questions
- Why should I take folic acid with methotrexate?
- How long does it take for methotrexate to work?
- Does methotrexate cause weight gain?
- How do I know if methotrexate is working for rheumatoid arthritis?
- What are the different brands of methotrexate?
- How long does methotrexate stay in your system?
- How does methotrexate work for ectopic pregnancy?
- What causes Plaque Psoriasis?
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.