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Elepsia XR Dosage

Medically reviewed by Drugs.com. Last updated on Sep 30, 2021.

Generic name: LEVETIRACETAM 1000mg
Dosage form: tablet, extended release

Recommended Dosing

ELEPSIA XR is administered orally once daily.

Initiate treatment with a dose of 1000 mg once daily. The once daily dosage may be adjusted in increments of 1000 mg every 2 weeks, to a maximum recommended daily dose of 3000 mg/day.

ELEPSIA XR should be taken whole; do not split or cut tablets.

Dosage Adjustment in Adult Patients with Renal Impairment

ELEPSIA XR is not recommended for use in patients with moderate or severe renal impairment. Recommended doses and adjustment for patients with mild renal impairment are shown in Table 1. In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated. To do this, an estimate of the patient's creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:

CLcr = [140-age (years)] × weight (kg) (× 0.85 for female patients)
72 × serum creatinine (mg/dL)

Then CLcr is adjusted for body surface area (BSA) as follows:

CLcr (mL/min/1.73m2) = CLcr (mL/min) × 1.73
BSA subject (m2)
Table 1: Dosing Adjustment Regimen for Adult Patients with Impaired Renal Function
Group Creatinine Clearance
(mL/min/1.73m2)
Dosage (mg) Frequency
Normal greater than 80 1000 to 3000 Every 24 hours
Mild 50 to 80 1000 to 2000 Every 24 hours

Discontinuation of ELEPSIA XR

When discontinuing ELEPSIA XR, reduce the dosage gradually and avoid abrupt discontinuation because of the risk of increased seizure frequency and status epilepticus [see Warnings and Precautions (5.7)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.