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Chlorpheniramine / Phenylephrine Dosage

Medically reviewed on March 20, 2017.

Applies to the following strengths: 9 mg-25 mg; 4.5 mg-5 mg; 4.5 mg-5 mg/5 mL; 1 mg-2.5 mg/5 mL; 2 mg-5 mg/5 mL; 4 mg-10 mg; 4 mg-20 mg; 4 mg-20 mg/5 mL; 2 mg-5 mg; 8 mg-20 mg; 4 mg-10 mg/5 mL; 2 mg-6 mg/mL; 2 mg-5 mg/mL; 3 mg-10 mg; 1 mg-3.5 mg/mL; 4 mg-12.5 mg/5 mL; 3 mg-7.5 mg/5 mL; 1 mg-2 mg/mL; 1 mg-2.5 mg/mL; 3.5 mg-10 mg; 8 mg-10 mg/5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

Immediate-release tablets: 1 tablet (2 mg-5 mg) every 4 to 6 hours as needed or 1 tablet (4 mg-10 mg or 3 mg-10 mg) every 4 hours as needed. Not to exceed 6 doses in 24 hours.
Immediate-release liquid: 5 mL (4 mg-10 mg/5 mL) or (4 mg-12.5 mg/5 mL) 3 to 4 times a day as needed

Sustained-release tablets: 1 tablet (8 mg-20mg) or (9 mg-25 mg) every 12 hours as needed.
or 1 to 2 tablet(s) (4 mg-20mg) every 12 hours as needed

Sustained-release suspension:
chlorpheniramine-phenylephrine (3 mg-7.5 mg/ 5 mL) extended release suspension
15 mL orally every 12 hours as needed.

Usual Adult Dose for Cold Symptoms

Immediate-release tablets: 1 tablet (2 mg-5 mg) every 4 to 6 hours as needed or 1 tablet (4 mg-10 mg or 3 mg-10 mg) every 4 hours as needed. Not to exceed 6 doses in 24 hours.
Immediate-release liquid: 5 mL (4 mg-10 mg/5 mL) or (4 mg-12.5 mg/5 mL) 3 to 4 times a day as needed

Sustained-release tablets: 1 tablet (8 mg-20mg) or (9 mg-25 mg) every 12 hours as needed.
or 1 to 2 tablet(s) (4 mg-20mg) every 12 hours as needed

Sustained-release suspension:
chlorpheniramine-phenylephrine (3 mg-7.5 mg/ 5 mL) extended release suspension
15 mL orally every 12 hours as needed.

Usual Pediatric Dose for Allergic Rhinitis

chlorpheniramine-phenylephrine (1 mg-3.5 mg/mL) oral drops:
6 months to 11 months: 0.75 mL orally 4 times a day.
1 year to 2 years: 1 mL orally 4 times a day.

chlorpheniramine-phenylephrine (1 mg-2 mg/mL) oral drops:
2 years to 5 years: 1 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.
6 years to 12 years: 2 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.

chlorpheniramine-phenylephrine 1 mg-2.5 mg/ 5 mL oral drops:
6 years to 12 years: 10 mL orally every 4 hours. Do not exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine 2 mg-5 mg/ml oral drops:
2 years to 5 years: 0.5 mL every 4 hours. Do not exceed 6 doses in 24 hours.
6 years to 12 years: 1 mL every 4 hours. Do not exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine (3 mg-7.5 mg/ 5 mL) extended release suspension:
2 to 5 years: 1.25 to 2.5 ml orally every 12 hours as needed.
6 to 11 years: 2.5 to 5 ml orally every 12 hours as needed.
12 years or older: 15 ml orally every 12 hours as needed.

chlorpheniramine-phenylephrine (4 mg-7.5 mg/ 20 mL) extended release suspension:
2 to 5 years: 2.5 ml orally every 12 hours as needed.
6 to 11 years: 5 ml orally every 12 hours as needed.
12 years or older: 10 ml orally every 12 hours as needed.

chlorpheniramine-phenylephrine (4 mg-10 mg or 3 mg-10 mg) oral tablet:
6 to 11 years: one half tablet orally every 4 hours as needed.
12 years or older: one tablet orally every 4 hours as needed.
Not to exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine (4 mg-12.5 mg/ 5 mL) oral syrup;
2 to 5 years: 1.25 ml orally every 4 hours to 6 hours, not to exceed 7.5 mL in 24 hours.
6 to 11 years: 2.5 ml orally every 4 hours to 6 hours, not to exceed 15 mL in 24 hours.
12 years or older: 5 ml orally every 4 hours to 6 hours, not to exceed 30 mL in 24 hours.

chlorpheniramine-phenylephrine (4.5 mg-5 mg/ 5 mL) extended release suspension:
2 to 5 years: 2.5 ml to 5 mL orally every 12 hours.
6 to 11 years: 2.5 ml to 10 mL orally every 12 hours.

chlorpheniramine-phenylephrine (4 mg-20 mg) extended release capsule:
6 to 12 years: one capsule orally every 12 hours, not to exceed 2 capsules in 24 hours.
12 years or older: two capsules orally every 12 hours, not to exceed 4 capsules in 24 hours.

chlorpheniramine-phenylephrine (8 mg-20 mg) extended release tablet:
6 to 12 years: one-half tablet orally every 12 hours.
12 years or older: one tablet orally every 12 hours.

Usual Pediatric Dose for Cold Symptoms

chlorpheniramine-phenylephrine (1 mg-3.5 mg/mL) oral drops:
6 months to 11 months: 0.75 mL orally 4 times a day.
1 year to 2 years: 1 mL orally 4 times a day.

chlorpheniramine-phenylephrine (1 mg-2 mg/mL) oral drops:
2 years to 5 years: 1 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.
6 years to 12 years: 2 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.

chlorpheniramine-phenylephrine 1 mg-2.5 mg/ 5 mL oral drops:
6 years to 12 years: 10 mL orally every 4 hours. Do not exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine 2 mg-5 mg/ml oral drops:
2 years to 5 years: 0.5 mL every 4 hours. Do not exceed 6 doses in 24 hours.
6 years to 12 years: 1 mL every 4 hours. Do not exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine (3 mg-7.5 mg/ 5 mL) extended release suspension:
2 to 5 years: 1.25 to 2.5 ml orally every 12 hours as needed.
6 to 11 years: 2.5 to 5 ml orally every 12 hours as needed.
12 years or older: 15 ml orally every 12 hours as needed.

chlorpheniramine-phenylephrine (4 mg-7.5 mg/ 20 mL) extended release suspension:
2 to 5 years: 2.5 ml orally every 12 hours as needed.
6 to 11 years: 5 ml orally every 12 hours as needed.
12 years or older: 10 ml orally every 12 hours as needed.

chlorpheniramine-phenylephrine (4 mg-10 mg or 3 mg-10 mg) oral tablet:
6 to 11 years: one half tablet orally every 4 hours as needed.
12 years or older: one tablet orally every 4 hours as needed.
Not to exceed 6 doses in 24 hours.

chlorpheniramine-phenylephrine (4 mg-12.5 mg/ 5 mL) oral syrup;
2 to 5 years: 1.25 ml orally every 4 hours to 6 hours, not to exceed 7.5 mL in 24 hours.
6 to 11 years: 2.5 ml orally every 4 hours to 6 hours, not to exceed 15 mL in 24 hours.
12 years or older: 5 ml orally every 4 hours to 6 hours, not to exceed 30 mL in 24 hours.

chlorpheniramine-phenylephrine (4.5 mg-5 mg/ 5 mL) extended release suspension:
2 to 5 years: 2.5 ml to 5 mL orally every 12 hours.
6 to 11 years: 2.5 ml to 10 mL orally every 12 hours.

chlorpheniramine-phenylephrine (4 mg-20 mg) extended release capsule:
6 to 12 years: one capsule orally every 12 hours, not to exceed 2 capsules in 24 hours.
12 years or older: two capsules orally every 12 hours, not to exceed 4 capsules in 24 hours.

chlorpheniramine-phenylephrine (8 mg-20 mg) extended release tablet:
6 to 12 years: one-half tablet orally every 12 hours.
12 years or older: one tablet orally every 12 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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