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Forteo (teriparatide) Disease Interactions

There are 6 disease interactions with Forteo (teriparatide):

Major

Parathyroid Hormone/Analogs (Includes Forteo) ↔ Malignancy

Severe Potential Hazard, Moderate plausibility

Applies to: Paget's Disease, Neoplasm of Bone

Parathyroid hormone and its analogs should not be used in patients who are at increased baseline risk for osteosarcoma. These agents should only be used if the potential benefits are considered to outweigh the potential risks. Monitor these patients according to clinical guidelines. Patients with bone metastases or a history of skeletal malignancies should not be treated with these agents.

Major

Teriparatide (Includes Forteo) ↔ Metabolic Bone Disorder

Severe Potential Hazard, Moderate plausibility

Applies to: Paget's Disease, Vitamin D Deficiency, Hungry Bone Syndrome, Osteodystrophy

The use of teriparatide in patients with metabolic bone disease, other than osteoporosis is not recommended by the manufacturer.

Moderate

Teriparatide (Includes Forteo) ↔ Hyperparathyroidism

Moderate Potential Hazard, Moderate plausibility

Applies to: Hyperparathyroidism

Patients known to have an underlying hypercalcemic disorder, such as primary hyperparathyroidism, should not be treated with teriparatide because of the risk of exacerbating hypercalcemia.

Moderate

Teriparatide (Includes Forteo) ↔ Orthostatic Hypotension

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypotension

There have been reports of transient episodes of symptomatic orthostatic hypotension with the use of teriparatide in short-term clinical pharmacology studies. Caution is recommended when using this agent in patients at risk.

Moderate

Teriparatide (Includes Forteo) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

No pharmacokinetic differences were identified in patients with mild or moderate renal impairment after a single dose of teriparatide. In patients with severe renal impairment, the AUC and half-life of teriparatide were increased by 73% and 77%, respectively. Care should be exercised in patients undergoing dialysis for chronic renal failure as no studies have been performed in this patient population.

Moderate

Teriparatide (Includes Forteo) ↔ Urolithiasis

Moderate Potential Hazard, Moderate plausibility

Applies to: Nephrolithiasis

Teriparatide should be used with caution in patients with active urolithiasis. If active or pre-existing hypercalciuria is suspected, measurement of urinary calcium excretion should be considered because of the potential to exacerbate urolithiasis in these patients.

Forteo (teriparatide) drug Interactions

There are 38 drug interactions with Forteo (teriparatide)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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