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Anectine Flo-Pack (succinylcholine) Disease Interactions

There are 2 disease interactions with Anectine Flo-Pack (succinylcholine):

Major

Neuromuscular Blocking Agents (Includes Anectine Flo-Pack) ↔ Histamine Release

Severe Potential Hazard, Moderate plausibility

Applies to: Allergies, Cardiovascular Disease, Asthma

Some neuromuscular blocking agents stimulate the release of histamine, which can cause wheezing, bronchospasm, increased bronchial secretions, hypotension, tachycardia, and circulatory collapse. Hypotension may also occur due to ganglionic blockade or as a complication of positive pressure respiration. Tubocurarine appears to be the most potent inducer of histamine, followed by metocurine (no longer commercially available in the U.S.) and succinylcholine. Other agents with varying but lesser degrees of histamine-releasing properties include atracurium, mivacurium, and pancuronium (at excessive dosages). Therapy with these neuromuscular blocking agents should be administered cautiously in patients with clinically significant cardiovascular disease and/or a history of asthma or severe allergic reactions. Certain agents may prolong the QTc interval, specially during general anesthesia in pediatric patients. The initial dosage and rate of administration may need to be reduced, and hemodynamic and respiratory status carefully monitored. Neuromuscular blocking agents that appear to have little or no histamine-inducing effects include cisatracurium, doxacurium, pipecuronium, rocuronium, and vecuronium.

References

  1. "Product Information. Tracrium (atracurium)." Glaxo Wellcome, Research Triangle Park, NC.
  2. "Product Information. Mivacron (mivacurium)." Glaxo Wellcome, Research Triangle Park, NC.
  3. "Product Information. Anectine (succinylcholine)." Glaxo Wellcome, Research Triangle Park, NC.
View all 7 references
Major

Neuromuscular Blocking Agents (Includes Anectine Flo-Pack) ↔ Pulmonary Impair

Severe Potential Hazard, High plausibility

Applies to: Pulmonary Impairment

Neuromuscular blocking agents can cause respiratory depression and paralysis. Therapy with neuromuscular blocking agents should be administered cautiously in patients with pulmonary impairment. Treatment of respiratory paralysis consists of positive-pressure artificial respiration with oxygen and maintenance of a patent airway until the recovery of normal respiration is assured.

References

  1. "Product Information. Tracrium (atracurium)." Glaxo Wellcome, Research Triangle Park, NC.
  2. "Product Information. Norcuron (vecuronium)." Organon, West Orange, NJ.
  3. "Product Information. Nuromax (doxacurium)." Glaxo Wellcome, Research Triangle Park, NC.
View all 7 references

Anectine Flo-Pack (succinylcholine) drug Interactions

There are 280 drug interactions with Anectine Flo-Pack (succinylcholine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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