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Reserpine Disease Interactions

There are 5 disease interactions with reserpine:

Major

Rauwolfia alkaloids (applies to reserpine) depression

Major Potential Hazard, High plausibility.

The use of rauwolfia alkaloids is contraindicated in patients with a history of mental depression, especially suicidal tendencies. Rauwolfia alkaloids depletes catecholamine and serotonin stores.

References

  1. Goodwin FK, Bunney WE, Jr "Depressions following reserpine: a reevaluation." Semin Psychiatry 3 (1971): 435-48
  2. Ambrosino SV "Depressive reactions associated with reserpine." N Y State J Med 74 (1974): 860-4
  3. Lewis WH "Iatrogenic psychotic depressive reaction in hypertensive patients." Am J Psychiatry 127 (1971): 1416-7
  4. Fleishman M "Letter: Reserpine, ECT, and depression." Am J Psychiatry 132 (1975): 1088
  5. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
View all 5 references
Major

Rauwolfia alkaloids (applies to reserpine) PUD/ulcerative colitis

Major Potential Hazard, High plausibility. Applicable conditions: Inflammatory Bowel Disease, Peptic Ulcer

The use of rauwolfia alkaloids is contraindicated in patients with active peptic ulcer or ulcerative colitis. Since rauwolfia alkaloids increase gastrointestinal motility and secretion, these conditions may be aggravated. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of peptic ulcer or ulcerative colitis because of the risk of reactivation.

References

  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Moderate

Antiadrenergic (peripheral) (applies to reserpine) peripheral edema

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Fluid Retention

Peripheral- acting antiadrenergic agents can cause peripheral edema. Therapy with peripheral- acting antiadrenergic agents should be administered cautiously in patients adversely affected by sodium and water retention.

References

  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Hylorel (guanadrel)." Rhone-Poulenc Rorer, Collegeville, PA.
  3. "Prazosin (Minipress) for hypertension." Med Lett Drugs Ther 19 (1977): 1-2
  4. "Product Information. Ismelin (guanethidine)." Ciba Pharmaceuticals, Summit, NJ.
  5. Weil JV, Chidsey CA "Plasma volume expansion resulting from interference with adrenergic function in normal man." Circulation 37 (1968): 54-61
  6. "Product Information. Cardura (doxazosin)." Pfizer US Pharmaceuticals, New York, NY.
  7. "Product Information. Hytrin (terazosin)." Abbott Pharmaceutical, Abbott Park, IL.
View all 7 references
Moderate

Rauwolfia alkaloids (applies to reserpine) biliary colic

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cholelithiasis

Rauwolfia alkaloids increase gastrointestinal motility and secretion and can precipitate biliary colic in patients with gallstones. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of gallstones.

References

  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
Moderate

Rauwolfia alkaloids (applies to reserpine) renal dysfunction

Moderate Potential Hazard, High plausibility.

In general, lowering the blood pressure may cause some decrease in renal function. Therefore, rauwolfia alkaloids should be used with caution in patients with renal impairment, since these patients may adjust poorly to the hypotensive effects of these agents.

References

  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

Reserpine drug interactions

There are 273 drug interactions with reserpine

Reserpine alcohol/food interactions

There is 1 alcohol/food interaction with reserpine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.