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Reserpine Disease Interactions

There are 2 disease interactions with reserpine:

Major

Rauwolfia Alkaloids (Includes Reserpine) ↔ Depression

Severe Potential Hazard, High plausibility

Applies to: Depression

The use of rauwolfia alkaloids is contraindicated in patients with a history of mental depression, especially suicidal tendencies. Rauwolfia alkaloids depletes catecholamine and serotonin stores.

References

  1. Goodwin FK, Bunney WE, Jr "Depressions following reserpine: a reevaluation." Semin Psychiatry 3 (1971): 435-48
  2. Lewis WH "Iatrogenic psychotic depressive reaction in hypertensive patients." Am J Psychiatry 127 (1971): 1416-7
  3. Fleishman M "Letter: Reserpine, ECT, and depression." Am J Psychiatry 132 (1975): 1088
  4. Ambrosino SV "Depressive reactions associated with reserpine." N Y State J Med 74 (1974): 860-4
  5. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
View all 5 references
Major

Rauwolfia Alkaloids (Includes Reserpine) ↔ Pud/Ulcerative Colitis

Severe Potential Hazard, High plausibility

Applies to: Inflammatory Bowel Disease, Peptic Ulcer

The use of rauwolfia alkaloids is contraindicated in patients with active peptic ulcer or ulcerative colitis. Since rauwolfia alkaloids increase gastrointestinal motility and secretion, these conditions may be aggravated. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of peptic ulcer or ulcerative colitis because of the risk of reactivation.

References

  1. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.

reserpine drug Interactions

There are 670 drug interactions with reserpine

reserpine alcohol/food Interactions

There is 1 alcohol/food interaction with reserpine

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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