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Nizatidine Disease Interactions

There are 2 disease interactions with nizatidine.


H2 antagonists (applies to nizatidine) GI bleeding

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.


  1. "Product Information. Pepcid (famotidine)." Merck & Company Inc (2002):
  2. "Product Information. Axid (nizatidine)." Lilly, Eli and Company (2002):
  3. "Product Information. Tagamet (cimetidine)." SmithKline Beecham (2001):
  4. "Product Information. Tritec (ranitidine bismuth citrate)." Glaxo Wellcome (2001):
  5. "Product Information. Zantac 75 (ranitidine)." Pfizer U.S. Pharmaceuticals (2002):
View all 5 references

Nizatidine (applies to nizatidine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Nizatidine and its metabolites are primarily eliminated by the kidney. Although the drug is generally well-tolerated, the daily dosage should be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min).


  1. Aronoff GR, Bergstrom RF, Bopp RJ, Sloan RS, Callaghan JT "Nizatidine disposition in subjects with normal and impaired renal function." Clin Pharmacol Ther 43 (1988): 688-95
  2. "Product Information. Axid (nizatidine)." Lilly, Eli and Company (2002):
  3. Gladziwa U, Klotz U "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet 27 (1994): 393-408

Nizatidine drug interactions

There are 86 drug interactions with nizatidine.

Nizatidine alcohol/food interactions

There is 1 alcohol/food interaction with nizatidine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.