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Methyldopa Disease Interactions

There are 8 disease interactions with methyldopa.

Major

Methyldopa (applies to methyldopa) liver disease

Major Potential Hazard, High plausibility.

The use of methyldopa is contraindicated in patients with active liver disease, such as active hepatitis or active cirrhosis, and in patients with previous methyldopa- associated liver disorders. Hepatotoxicity is an uncommon but toxic effect of methyldopa. Therapy with methyldopa should be administered cautiously in patients with a history of or predisposition to liver disease.

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Moderate

Methyldopa (applies to methyldopa) cerebrovascular disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Cerebrovascular Disease

Rarely, involuntary choreoathetotic movements have been observed during therapy with methyldopa in patients with severe bilateral cerebrovascular disease. If these movements occur, therapy should be stopped.

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Moderate

Methyldopa (applies to methyldopa) dialysis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: hemodialysis

Methyldopa is removed by dialysis. Patients receiving methyldopa and undergoing dialysis may occasionally become hypertensive.

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Moderate

Methyldopa (applies to methyldopa) hemolytic anemia

Moderate Potential Hazard, Low plausibility. Applicable conditions: Bleeding

Hemolytic anemia has occurred rarely during therapy with methyldopa and may be associated with a (+) direct Coombs. Therapy with methyldopa should be administered cautiously to patients with anemia or a predisposition to hemolytic syndromes. Clinical monitoring of hematopoietic function, including a baseline hematological profile, is recommended. If Coombs- positive hemolytic anemia occurs, the cause may be methyldopa and the drug should be discontinued

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Moderate

Methyldopa (applies to methyldopa) leukopenia

Moderate Potential Hazard, Low plausibility. Applicable conditions: Neutropenia

Rare reports of reversible reduction in white blood cell count, primarily neutrophils, have been noted. White blood cell counts returned to normal with discontinuation of methyldopa. Therapy with methyldopa should be administered cautiously in patients with a history of or predisposition to decreased white blood cell or neutrophil counts. Clinical monitoring of hematopoietic function is recommended.

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Moderate

Methyldopa (applies to methyldopa) peripheral edema

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure, Fluid Retention

Methyldopa may cause edema or weight gain associated with sodium retention. Therapy with methyldopa should be administered cautiously in patients adversely affected by sodium and water retention.

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Moderate

Methyldopa (applies to methyldopa) pheochromocytoma

Moderate Potential Hazard, Moderate plausibility.

Methyldopa causes fluorescence in urine samples at the same wave lengths as catecholamines, falsely high levels of urinary catecholamines may be reported. This will interfere with the diagnosis of pheochromocytoma. It is important to recognize this phenomenon before a patient with a possible pheochromocytoma is subjected to surgery. Methyldopa is not recommended for the treatment of patients with pheochromocytoma.

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Minor

Methyldopa (applies to methyldopa) psychoses

Minor Potential Hazard, Low plausibility. Applicable conditions: Psychosis

Rare symptoms of psychoses, such as hallucinations and delirium, and vivid dreams and nightmares have been reported during methyldopa therapy. Therapy with methyldopa should be administered cautiously to patients with a history of or predisposition to these conditions.

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Methyldopa drug interactions

There are 310 drug interactions with methyldopa.

Methyldopa alcohol/food interactions

There are 2 alcohol/food interactions with methyldopa.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.