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Xyzal Disease Interactions

There are 2 disease interactions with Xyzal (levocetirizine).


Levocetirizine (applies to Xyzal) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The use of levocetirizine is contraindicated in patients with end-stage renal disease (CrCl < 10 mL/min), and in patients undergoing hemodialysis. It is also contraindicated in pediatric patients (ages 6 months to 11 years) with impaired renal function. Levocetirizine is excreted by the kidneys and the risk of adverse reactions is greater in patients with renal impairment. Caution is advised.


  1. (2007) "Product Information. Xyzal (levocetirizine)." UCB Pharma Inc

Levocetirizine (applies to Xyzal) urinary retention

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Urinary Tract Obstruction

Urinary retention has been reported postmarketing in patients using levocetirizine. Caution is advised in patients with predisposing factors of urinary retention such as patients with prostatic hyperplasia, or spinal cord lesions.


  1. (2007) "Product Information. Xyzal (levocetirizine)." UCB Pharma Inc

Xyzal drug interactions

There are 258 drug interactions with Xyzal (levocetirizine).

Xyzal alcohol/food interactions

There is 1 alcohol/food interaction with Xyzal (levocetirizine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.