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Lemborexant Disease Interactions

There are 4 disease interactions with lemborexant:

Moderate

Lemborexant (applies to lemborexant) alcohol

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Alcoholism

Patients treated with lemborexant should not consume alcohol as it can increase drowsiness and also the incidence of adverse effects.

Moderate

Lemborexant (applies to lemborexant) COPD

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Pulmonary Impairment

Lemborexant has not been studied in patients with moderate to severe obstructive sleep apnea (OSA) or in patients with chronic obstructive pulmonary disease. Caution is advised if prescribing to patients with compromised respiratory function.

Moderate

Lemborexant (applies to lemborexant) depression

Moderate Potential Hazard, Moderate plausibility.

Worsening of depression and suicidal thoughts and actions have been reported with the use of lemborexant. Caution is advised in patients with depression. Protective measures may be required in patients with suicidal tendencies, including prescription of the lowest number of tablets at one time.

Moderate

Lemborexant (applies to lemborexant) liver impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Lemborexant has not been studied in patients with severe liver dysfunction (Child-Pugh Class C). Its use is not recommended in these patients.

Lemborexant drug interactions

There are 490 drug interactions with lemborexant

Lemborexant alcohol/food interactions

There are 3 alcohol/food interactions with lemborexant

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.