Heartburn Relief Maximum Strength (famotidine) Disease Interactions
There are 2 disease interactions with Heartburn Relief Maximum Strength (famotidine):
H2 Antagonists (Includes Heartburn Relief Maximum Strength) ↔ Gi Bleeding
Severe Potential Hazard, Moderate plausibility
Applies to: Gastrointestinal Hemorrhage
Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.
Famotidine (Includes Heartburn Relief Maximum Strength) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Famotidine is partially eliminated by the kidney as unchanged drug, the extent of which is dependent upon the route of administration (25% to 30% oral; 65% to 70% intravenous). The elimination half-life of famotidine may be prolonged considerably in patients with severe renal impairment (CrCl < 10 mL/min), possibly exceeding 20 hours and approaching approximately 24 hours in anuric patients. Since central nervous system adverse effects such as grand mal seizures and psychic disturbances have been reported in patients with moderate (CrCl < 50 mL/min) and severe renal impairment, dosage adjustments are recommended for these patients. Reducing the normally recommended dosage by one-half or prolonging the dosing interval to 36 to 48 hours may be appropriate, depending on the patient's clinical response.
- Halstenson CE, Abraham PA, Opsahl JA, Chremos AN, Keane WF, Matzke GR "Disposition of famotidine in renal insufficiency." J Clin Pharmacol 27 (1987): 782-7
- Gladziwa U, Klotz U "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet 27 (1994): 393-408
- Kroemer H, Klotz U "Pharmacokinetics of famotidine in man." Int J Clin Pharmacol Ther Toxicol 25 (1987): 458-63
Heartburn Relief Maximum Strength (famotidine) drug Interactions
There are 162 drug interactions with Heartburn Relief Maximum Strength (famotidine)
Heartburn Relief Maximum Strength (famotidine) alcohol/food Interactions
There is 1 alcohol/food interaction with Heartburn Relief Maximum Strength (famotidine)
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.