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ParaGard (copper topical) Disease Interactions

There are 6 disease interactions with ParaGard (copper topical):

Major

Copper (applies to ParaGard) uterus abnormalities

Major Potential Hazard, Moderate plausibility. Applicable conditions: Abnormal Uterine Bleeding, Abdominopelvic Fistulas, Endometrial Dysplasia, Infection - Bacterial/Fungal/Protozoal/Viral

The use of copper for intrauterine contraception is contraindicated when there are abnormalities of the uterus resulting in distortion of the uterine cavity, acute pelvic inflammatory disease, or current behavior suggesting a high risk for pelvic inflammatory disease, known or suspected uterine or cervical malignancy, postpartum endometritis or postabortal endometritis in the past 3 months, known or suspected uterine or cervical malignancy, genital bleeding of unknown etiology, or mucopurulent cervicitis.

Moderate

Copper (applies to ParaGard) immunodeficiency

Moderate Potential Hazard, Moderate plausibility.

The use of copper for intrauterine contraception should not be placed in women with AIDS unless they are clinically stable on antiretroviral therapy. Little is known about the use of intrauterine devices (IUDs) in women who have illnesses causing serious immunocompromise. Therefore, these women should be carefully monitored for infection if they choose to use an IUD.

Moderate

Copper (applies to ParaGard) metabolic disorder

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Metabolic Disorder - Congenital

It is not recommended to administer copper to a patient with Wilson's Disease, a genetic disease of copper metabolism.

Moderate

Copper (applies to ParaGard) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Certain copper injectable formulations contain aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Patients with impaired kidney function who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. Care is recommended when using this agent in patients with renal disease.

Moderate

Copper/manganese (applies to ParaGard) elimination

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Biliary Obstruction, Liver Disease

The trace elements, copper and manganese, are excreted in the bile. Copper and manganese doses may need to be adjusted, reduced, or omitted in patients with liver disease or biliary obstruction.

References

  1. "Product Information. Copper Sulfate (copper sulfate)." Humco Holding Group, Texarkana, TX.
  2. "Product Information. Manganese Sulfate (manganese sulfate)." American Regent Laboratories Inc, Shirley, NY.
  3. "Product Information. Manganese Chloride (manganese chloride)." Abbott Pharmaceutical, Abbott Park, IL.
Moderate

Trace metals (applies to ParaGard) malabsorption syndromes

Moderate Potential Hazard, Moderate plausibility.

The trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.

References

  1. "Product Information. Chroma-Pak (chromic chloride)." Abbott Pharmaceutical, Abbott Park, IL.
  2. "Product Information. Manganese Chloride (manganese chloride)." Abbott Pharmaceutical, Abbott Park, IL.
  3. "Product Information. Sele-Pak (selenious acid)." Fujisawa, Deerfield, IL.
  4. "Product Information. Manganese Sulfate (manganese sulfate)." American Regent Laboratories Inc, Shirley, NY.
  5. "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA, North Wales, PA.
  6. "Product Information. Copper Sulfate (copper sulfate)." Humco Holding Group, Texarkana, TX.
View all 6 references

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.