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Acid Reducer-Cimetidine Disease Interactions

There are 4 disease interactions with Acid Reducer-Cimetidine (cimetidine).

Major

Cimetidine (applies to Acid Reducer-Cimetidine) liver disease

Major Potential Hazard, Moderate plausibility.

Cimetidine is partially metabolized by the liver, and to a greater extent when administered orally than when given intravenously. Although dosage reductions are generally not necessary, therapy with cimetidine should be administered cautiously in patients with liver disease. Hepatotoxicity has been associated with cimetidine use. In addition, liver disease appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are usually reversible within 3 to 4 days after discontinuation of therapy.

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Major

H2 antagonists (applies to Acid Reducer-Cimetidine) GI bleeding

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage

Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.

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Moderate

Cimetidine (applies to Acid Reducer-Cimetidine) hemodialysis

Moderate Potential Hazard, High plausibility.

Cimetidine is partially removed by hemodialysis and should be administered after dialysis.

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Moderate

Cimetidine (applies to Acid Reducer-Cimetidine) renal dysfunction

Moderate Potential Hazard, High plausibility.

Cimetidine and its metabolites are primarily eliminated by the kidney. The daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution. Renal dysfunction also appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are generally reversible within 3 to 4 days after discontinuation of therapy.

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Acid Reducer-Cimetidine drug interactions

There are 466 drug interactions with Acid Reducer-Cimetidine (cimetidine).

Acid Reducer-Cimetidine alcohol/food interactions

There are 3 alcohol/food interactions with Acid Reducer-Cimetidine (cimetidine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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