Calcium carbonate / famotidine / magnesium hydroxide Disease Interactions
There are 3 disease interactions with calcium carbonate / famotidine / magnesium hydroxide:
H2 Antagonists (Includes Calcium carbonate/famotidine/magnesium hydroxide) ↔ Gi Bleeding
Severe Potential Hazard, Moderate plausibility
Applies to: Gastrointestinal Hemorrhage
Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.
Magnesium Salts (Includes Calcium carbonate/famotidine/magnesium hydroxide) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.
- "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
- "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
- "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
Famotidine (Includes Calcium carbonate/famotidine/magnesium hydroxide) ↔ Renal Dysfunction
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Famotidine is partially eliminated by the kidney as unchanged drug, the extent of which is dependent upon the route of administration (25% to 30% oral; 65% to 70% intravenous). The elimination half-life of famotidine may be prolonged considerably in patients with severe renal impairment (CrCl < 10 mL/min), possibly exceeding 20 hours and approaching approximately 24 hours in anuric patients. Since central nervous system adverse effects such as grand mal seizures and psychic disturbances have been reported in patients with moderate (CrCl < 50 mL/min) and severe renal impairment, dosage adjustments are recommended for these patients. Reducing the normally recommended dosage by one-half or prolonging the dosing interval to 36 to 48 hours may be appropriate, depending on the patient's clinical response.
- Halstenson CE, Abraham PA, Opsahl JA, Chremos AN, Keane WF, Matzke GR "Disposition of famotidine in renal insufficiency." J Clin Pharmacol 27 (1987): 782-7
- Gladziwa U, Klotz U "Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure." Clin Pharmacokinet 27 (1994): 393-408
- Kroemer H, Klotz U "Pharmacokinetics of famotidine in man." Int J Clin Pharmacol Ther Toxicol 25 (1987): 458-63
calcium carbonate / famotidine / magnesium hydroxide drug Interactions
There are 643 drug interactions with calcium carbonate / famotidine / magnesium hydroxide
calcium carbonate / famotidine / magnesium hydroxide alcohol/food Interactions
There is 1 alcohol/food interaction with calcium carbonate / famotidine / magnesium hydroxide
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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