Vicks NyQuil Cold & Flu Nighttime Relief Alternatives Compared
| Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) | Benadryl (diphenhydramine) | Diphenhydramine |
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| Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) | Benadryl (diphenhydramine) | Diphenhydramine |
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Over-the-counter
Prescribed for Cold Symptoms, Cough. Vicks NyQuil Cold & Flu Nighttime Relief may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Benadryl is used to treat allergies, motion sickness, and to relieve symptoms of Parkinson's Disease (PD) in patients unable to tolerate more potent agents. It may also be used off-label to help... View more |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
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| More about Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine) | More about Benadryl (diphenhydramine) | More about Diphenhydramine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Vicks NyQuil Cold & Flu Nighttime Relief has an average rating of 2.0 out of 10 from a total of 1 ratings on Drugs.com. 0% of reviewers reported a positive effect, while 100% reported a negative effect. |
Benadryl has an average rating of 7.0 out of 10 from a total of 80 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 543 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
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View all Vicks NyQuil Cold & Flu Nighttime Relief side effects |
View all Benadryl side effects |
View all Diphenhydramine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Benadryl prices |
View all Diphenhydramine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Other acetaminophen / dextromethorphan / doxylamine brands include: Alka-Seltzer Plus Severe Cold+Cough Night Liquid, Clear Cough PM Multi-Symptom, Contac Cold + Flu (Night) Cooling Relief Liquid, Coricidin HBP Nighttime Multi-Symptom Cold, Delsym Night Time Cough & Cold, Multi Symptom NiteTime, Night Time Multi Symptom Cold/Flu Relief, Robitussin Cold + Flu (Nighttime), Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime, Tylenol Cough & Sore Throat Nightime, Vicks Nature Fusion Cold & Flu Nighttime Relief, Vicks NyQuil HBP Cold & Flu View more | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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N/A |
9.3 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category N
Not classified
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 533 drugs are known to interact with Vicks NyQuil Cold & Flu Nighttime Relief:
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A total of 449 drugs are known to interact with Benadryl:
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A total of 449 drugs are known to interact with Diphenhydramine:
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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N/A |
March 04, 1946 |
March 04, 1946 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Promethazine DM
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.