Comparing Tofacitinib vs Upadacitinib

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tofacitinib	Upadacitinib	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tofacitinib	Upadacitinib	Enter another drug to compare
Prescription only Prescribed for Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis, Polyarticular Juvenile Idiopathic Arthritis. Tofacitinib may also be used for purposes not listed... View more	Prescription only Prescribed for Crohn's Disease, Ankylosing Spondylitis, Atopic Dermatitis, Non-Radiographic Axial Spondyloarthritis, Polyarticular Juvenile Idiopathic Arthritis, Giant Cell Arteritis, Psoriatic... View more	Related suggestions Rheumatoid Arthritis Methotrexate Humira Hydroxychloroquine Prednisone Meloxicam Celebrex Psoriatic Arthritis Methotrexate Humira Otezla Cosentyx Enbrel Stelara Ulcerative Colitis Mesalamine Lialda Humira Budesonide Entyvio Sulfasalazine Ankylosing Spondylitis Humira Celebrex Cosentyx Enbrel Prednisone Diclofenac
More about Tofacitinib	More about Upadacitinib
Ratings & Reviews
Tofacitinib has an average rating of 5.7 out of 10 from a total of 172 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 40% reported a negative effect.	Upadacitinib has an average rating of 7.0 out of 10 from a total of 232 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 18% reported a negative effect.
View all 172 reviews	View all 232 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Headaches (9.9%) Fatigue (7.6%) Upset stomach (7.0%) Nausea (6.4%) Diarrhea (5.8%) Swelling (4.7%) Pain (4.1%) View all Tofacitinib side effects	Acne (9.5%) Dizziness (7.3%) Nausea (7.3%) Fatigue (6.5%) Headaches (5.6%) Swelling (5.6%) Tiredness (5.2%) View all Upadacitinib side effects
Drug Class
Antirheumatics	Antirheumatics
Generic Availability
N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
N/A	N/A
Brand Names
Xeljanz, Xeljanz Oral Solution, Xeljanz XR	Rinvoq, Rinvoq LQ
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
3 hours	14 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.
Drug Interactions
A total of 659 drugs are known to interact with Tofacitinib: 378 major drug interactions (1239 brand and generic names) 270 moderate drug interactions (1033 brand and generic names) 11 minor drug interactions (42 brand and generic names)	A total of 599 drugs are known to interact with Upadacitinib: 380 major drug interactions (1251 brand and generic names) 209 moderate drug interactions (852 brand and generic names) 10 minor drug interactions (40 brand and generic names)
Alcohol/Food/Lifestyle Interactions
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.	Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be... View more
Disease Interactions
Cardiovascular risk Malignancy Thrombosis Infections Tuberculosis viral reactivation Cytopenias Diabetes GI obstruction GI perforation Hepatic disorder Hyperlipidemia Renal disease	Cardiovascular risk Malignancy Thrombosis Infections Cytopenias Gastrointestinal perforation Hepatic impairment Hyperlipidemia Vaccination
First Approval Date
November 06, 2012	August 16, 2019
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Support group En español
Patient Resources
Tofacitinib uses	Upadacitinib uses
Professional Resources
Monograph (AHFS) Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Ankylosing Spondylitis Rheumatoid Arthritis Psoriatic Arthritis Ulcerative Colitis Polyarticular Juvenile Idiopathic Arthritis	Crohn's Disease Ankylosing Spondylitis Atopic Dermatitis Non-Radiographic Axial Spondyloarthritis Polyarticular Juvenile Idiopathic Arthritis Giant Cell Arteritis Psoriatic Arthritis Rheumatoid Arthritis Ulcerative Colitis show all

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Tofacitinib vs Upadacitinib

Further information

Compare Drugs