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Tofacitinib and Swelling: What Users Say

Brand names: Xeljanz, Xeljanz XR, Xeljanz Oral Solution

Swelling: mentioned by 8 users (4.7%)

Based on user experiences from 172 Tofacitinib reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 9.9%
fatigue 7.6%
upset stomach 7.0%
nausea 6.4%
diarrhea 5.8%
swelling 4.7%
pain 4.1%
weight gain 4.1%
depression 3.5%
high blood pressure 3.5%

Reviews for Tofacitinib

Showing 8 reviews tagged with "swelling". Clear filters to view all 172 reviews.
Commonly mentioned side effects
  • Bri...
  • Taken for 1 to 6 months
  • March 27, 2020

For Rheumatoid Arthritis "Been on this Xeljanz poison for three and a half months. I got worse and worse with pain. Muscle weakness. Enlarged liver. Terrible stomach problems, excruciating pain in my guts, and constant nausea. Liver pain, swelling in feet, hands, wrists, and general unwell feeling. Developed chest infections. The chemist ran out, so I was without it for three days. Stomach... good! No liver pain!!! Not one ounce of swelling. Night sweats stopped. Burning up feeling stopped. Day one back on it... all symptoms back!!! Dreadful poison. I'm stopping it."

1 / 10
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  • Ema...
  • Taken for 6 months to 1 year
  • April 20, 2019

For Rheumatoid Arthritis "I'm 19 and have been on Xeljanz for around 6 months. I take it along with methotrexate, which I have done with all of my other treatment options. I've struggled with catching anything and everything since starting this med, and when I get sick, I have trouble fighting it off. From stomach bugs, ear infections, colds, anything. I have never struggled this much with catching things, and seemingly small issues end up turning serious and landing me in the hospital. Other than this, I have also struggled a lot with joint swelling on this drug. Not sure if I will be able to stick with this."

6 / 10
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43 Report
  • Jul...
  • Taken for 1 to 6 months
  • January 7, 2017

For Rheumatoid Arthritis "I could tell it was going to work from the second day and had a wonderful 6 or so pain-free weeks until it started to stop working. Having bad flares again at the 2-month mark-swelling seems to still be slightly controlled, but pain and stiffness are bad and about to turn to prednisone."

6 / 10
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31 Report

Frequently asked questions

  • Ama...
  • Taken for 1 to 6 months
  • October 19, 2022

For Rheumatoid Arthritis "I have been taking Xeljanz for 4 months now. I have experienced less joint pain and swelling in some joints but increased significantly in other joints to the point of crying. Extreme fatigue, dizziness, nausea, and a general unwell sick feeling. I was previously on other biologics and then just on prednisone. I would much rather feel the way I felt before taking the Xeljanz. The way I feel on this drug is worse than being on nothing."

1 / 10
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6 Report
  • Los...
  • Taken for less than 1 month
  • September 26, 2017

For Rheumatoid Arthritis "On my 3rd week with no improvement, increased pain, swelling, and fever exponentially increased, (not 'core' temp just 'hot joints') decreased energy, frequent headache, and increased depression! I didn't know any of these things could get worse than they already were. But they have! :-( Hanging in there because mine is in every single joint and 'unrelenting.' I don't really have flares 'cause mine is constant daily (and nightly) pain, swelling, the fever."

4 / 10
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13 Report

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  • Kim...
  • Taken for 1 to 6 months
  • July 2, 2024

For Rheumatoid Arthritis "Worked in about 1 month. 5 mg twice a day with hydrochloroquine (plaquenil). No side effects!! I am also super sensitive to most meds, for anything! Tried Humira and Enbrel. Those BOTH I had swelling, headaches (bad), diarrhea. Just all around sick."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 2, 2024

For Rheumatoid Arthritis "Worked in about 1 month. 5 mg twice a day with hydrochloroquine (plaquenil). No side effects!! I am also super hyper-reactions to most meds, for anything! Tried Humira and Enbrel. Those BOTH I had swelling, headaches (bad), diarrhea. Just all around sick."

10 / 10
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  • Blo...
  • May 29, 2014

For Rheumatoid Arthritis "Worked amazingly the first month, but then swelling and stiffness came back. I've also had hair loss."

9 / 10
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60 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.