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Sutent Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Sutent Votrient Afinitor
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Sutent (sunitinib) Votrient (pazopanib) Afinitor (everolimus)
Prescription only

Sutent is an oral capsule that may be taken once daily to treat certain types of RCC and other advanced cancers. It may be taken every day or for 4 weeks on, 2 weeks off schedule. It has been... View more

Prescription only

Prescribed for Soft Tissue Sarcoma, Renal Cell Carcinoma. Votrient may also be used for purposes not listed in this medication guide.

Prescription only

Afinitor (everolimus) is a targeted medicine that may be used to treat various cancers and TSC-associated conditions. It reduces the blood supply to the cancers which slows down their growth and... View more

Related suggestions
More about Sutent (sunitinib) More about Votrient (pazopanib) More about Afinitor (everolimus)
Generic Status

Lower-cost generic is available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Sutent has an average rating of 7.5 out of 10 from a total of 30 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 19% reported a negative effect.

Votrient has an average rating of 8.2 out of 10 from a total of 81 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 7% reported a negative effect.

Afinitor has an average rating of 5.4 out of 10 from a total of 20 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 42% reported a negative effect.

View all 30 reviews

View all 81 reviews

View all 20 reviews

Drug Class
Side Effects

Common side effects include:

  • oral candidiasis
  • asthenia
  • decreased left ventricular ejection fraction
  • diarrhea
  • hypokalemia
  • lymphocytopenia
  • mucositis
  • neutropenia
  • vomiting
  • hypertension
  • show all 10

See also: Sutent side effects in more detail.

Common side effects include:

  • bleeding tendency disorder
  • abdominal pain
  • decreased serum glucose
  • decreased serum magnesium
  • decreased serum phosphate
  • diarrhea
  • fatigue
  • hypertension
  • increased serum alanine aminotransferase
  • increased serum aspartate aminotransferase
  • increased serum bilirubin
  • leukopenia
  • nausea
  • neutropenia
  • thrombocytopenia
  • vomiting
  • anorexia
  • show all 17

See also: Votrient side effects in more detail.

Common side effects include:

  • infection
  • decreased hemoglobin
  • increased serum glucose
  • lymphocytopenia
  • stomatitis

See also: Afinitor side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 28 capsule
Dosage 12.5 mg
Per Unit* $236.07
Cost* $6,610.09

View all Sutent prices and generic prices

Quantity 120 tablet
Dosage 200 mg
Per Unit* $134.84 - $148.18
Cost* $16,180.78 - $17,781.74

View all Votrient prices

Quantity 28 each
Dosage 2.5 mg
Per Unit* $651.99
Cost* $18,255.85

View all Afinitor prices and generic prices

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Dosage Form(s) Available
  • Oral capsule
  • Oral tablet
  • Oral tablet
Brand Names

N/A

N/A

 Other everolimus brands include: Afinitor Disperz, Zortress
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

60 hours

30.9 hours

35 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 419 drugs are known to interact with Sutent:

  • 85 major drug interactions (230 brand and generic names)
  • 333 moderate drug interactions (1191 brand and generic names)
  • 1 minor drug interactions (2 brand and generic names)

A total of 627 drugs are known to interact with Votrient:

  • 155 major drug interactions (534 brand and generic names)
  • 459 moderate drug interactions (1562 brand and generic names)
  • 13 minor drug interactions (30 brand and generic names)

A total of 478 drugs are known to interact with Afinitor:

  • 169 major drug interactions (652 brand and generic names)
  • 301 moderate drug interactions (809 brand and generic names)
  • 8 minor drug interactions (37 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • SUNItinib may be taken with or without food. If you are receiving therapy with SUNItinib you... View more
  • Do not consume grapefruit or grapefruit juice during treatment with PAZOPanib unless directed... View more
  • Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink... View more
Disease Interactions
First Approval Date

N/A

N/A

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A

N/A

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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