Comparing Rexulti vs Trintellix

For Major Depressive Disorder I have been on Rexulti for a little over a month now and it has basically been a godsend. The first week or two I cried nonstop at almost anything. Happy things. Sad things. Funny things. It was more of a delusional cry than a depressive/sad cry. It was really annoying but went away after about 1-2 weeks. I have not gained any weight, which I’m super thankful for. The only side effect I've really had is the fatigue. I’m so tired every single day that I’ve started taking naps. I never take naps. I’ve also started drinking coffee in the mornings to keep myself awake. I’ve also never been a coffee drinker. These two things are starting to worry me a bit because it’s almost interfering with my schoolwork and daily function. But I love this medication otherwise and don’t want to consider anything else if it’s really helping me.

For Major Depressive Disorder I have been diagnosed over the years, in turn, as having (1) atypical anxiety; (2) PTSD; (3) bipolar 2; (4) MDD. I have been on many drugs over the years and most recently, Zoloft (stopped due to severe insomnia); Cymbalta (stopped due to sexual side effects); Latuda (stopped due to insomnia) and most recently, Rexulti. My mood and depression have greatly improved over the course of a week being on this drug, but the insomnia it engenders is very difficult. I wake every 2 hours and have to really work, with relaxation tapes, to get back to sleep, or I occasionally take .5 mg Klonopin. I have an extremely demanding work life and the lack of sleep is a big issue. If it resolves, I will say I'm very satisfied with this drug.

For Depression I've been on trintellix for 10 weeks now, roughly. I was on 5mg for awhile, now on ten. At first the nausea was unbearable and all it really did was stop me from getting overwhelmingly sad as often but now I've found that I'm more outgoing and capable of trying my best even in uncomfortable situations. The nausea is still there but it becomes super tolerable and gravol is a lifesaver. The only time it became a problem is when I was sick, I vomited non-stop, I had bronchitis so apparently the throat pain mixed with nausea was to blame. Still, overall trintellix has done wonders for my mental health and I'm hoping the majority of others can agree or find another medication that will do for you, what trintellix has done for me.

For Depression Just a reminder for anyone taking the drug and reading these reviews, it take's at least a week or two before one can begin to feel the beneficial results. As for my personal experience; I'm one week on the drug, and I'm taking Ativan as well to treat MDD and anxiety disorders. Other than some rather uncomfortable nausea, and a day or two of vomiting, this has been a very beneficial experience. No weight gain, libido is intact, and I feel clear; however, I strongly recommend you not do any heavy drinking while on this drug, and if you have a history of heart burn or stomach ulcers, then it might be a good idea to use additional medication to treat any stomach problems. All in all, it's working for me =)