Comparing Rexulti vs Trintellix

For Major Depressive Disorder Mixed bag. On the positive side, it can pull you out of a dark hole really quick. On the negative, I'm starting to suspect it is causing a lot of my anger and irritation symptoms to go off the charts. I'm going to try going off of it for a few days again and if that makes me feel better, time to call my doc for something else.

For Major Depressive Disorder I have been on Rexulti for a little over a month now and it has basically been a godsend. The first week or two I cried nonstop at almost anything. Happy things. Sad things. Funny things. It was more of a delusional cry than a depressive/sad cry. It was really annoying but went away after about 1-2 weeks. I have not gained any weight, which I’m super thankful for. The only side effect I've really had is the fatigue. I’m so tired every single day that I’ve started taking naps. I never take naps. I’ve also started drinking coffee in the mornings to keep myself awake. I’ve also never been a coffee drinker. These two things are starting to worry me a bit because it’s almost interfering with my schoolwork and daily function. But I love this medication otherwise and don’t want to consider anything else if it’s really helping me.

For Depression I tried Trintellix 5mg for a week but had the worst nausea. No change with food or when taking it before bed. Every time, about 30 minutes after taking it, the nausea kicked in: I would feel the acid rising, stomach irritation, and my gag reflex get really sensitive. I had to sit still and fight off the strong urge to vomit for about 2 hours until it eventually subsided. I read that some people had less nausea over time, but I just couldn't stick it out and work/live my life. It's a bummer because I felt so much better emotionally, I really wanted to continue it. I just don't know why it causes such intense stomach upset :( Currently I'm trying 100mg Wellbutrin again and might ask to add an SSRI to that as well.

For Depression I've been on trintellix for 10 weeks now, roughly. I was on 5mg for awhile, now on ten. At first the nausea was unbearable and all it really did was stop me from getting overwhelmingly sad as often but now I've found that I'm more outgoing and capable of trying my best even in uncomfortable situations. The nausea is still there but it becomes super tolerable and gravol is a lifesaver. The only time it became a problem is when I was sick, I vomited non-stop, I had bronchitis so apparently the throat pain mixed with nausea was to blame. Still, overall trintellix has done wonders for my mental health and I'm hoping the majority of others can agree or find another medication that will do for you, what trintellix has done for me.