Comparing Rexulti vs Trintellix
| Rexulti | Trintellix |
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| Rexulti (brexpiprazole) | Trintellix (vortioxetine) |
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Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression. Most people experience some improvement in their symptoms within 1 to 2 weeks of starting... View more |
Prescription only
Trintellix may be used to treat depression in adults. It is different from other antidepressants currently on the market because it directly affects serotonin receptors as well as inhibits serotonin... View more |
Related suggestions Depression
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| More about Rexulti (brexpiprazole) | More about Trintellix (vortioxetine) | ||||||||||||||||
| Generic Status | |||||||||||||||||
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No lower-cost generic available |
No lower-cost generic available |
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| Ratings & Reviews | |||||||||||||||||
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Rexulti has an average rating of 6.4 out of 10 from a total of 401 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 28% reported a negative effect. |
Trintellix has an average rating of 5.9 out of 10 from a total of 1045 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 34% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: Rexulti side effects in more detail. |
Common side effects include:
See also: Trintellix side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Rexulti prices |
View all Trintellix prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
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N/A |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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91 hours |
66 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 539 drugs are known to interact with Rexulti:
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A total of 338 drugs are known to interact with Trintellix:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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July 10, 2015 |
September 30, 2013 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.