Comparing Phenergan vs Unisom SleepMelts
| Phenergan (promethazine) | Unisom SleepMelts (diphenhydramine) |
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| Phenergan (promethazine) | Unisom SleepMelts (diphenhydramine) |
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Prescription only
Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Sedation is the main side effect. Occasionally, paradoxical reactions (the opposite of what is to be expected) may... View more |
Prescription and OTC
Prescribed for Insomnia. Unisom SleepMelts may also be used for purposes not listed in this medication guide. |
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| More about Phenergan (promethazine) | More about Unisom SleepMelts (diphenhydramine) | ||||||||
| Ratings & Reviews | |||||||||
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Phenergan has an average rating of 7.4 out of 10 from a total of 153 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 21% reported a negative effect. |
Unisom SleepMelts has an average rating of 9.0 out of 10 from a total of 2 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Phenergan side effects |
View all Unisom SleepMelts side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
View all Phenergan prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other promethazine brands include: Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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16 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 690 drugs are known to interact with Phenergan:
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A total of 449 drugs are known to interact with Unisom SleepMelts:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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March 29, 1951 |
N/A |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
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N/A |
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| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.