Comparing Lexapro vs Wellbutrin XL

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Lexapro escitalopram

Wellbutrin XL bupropion

Lexapro is an effective antidepressant that may have less potential for adverse effects than other SSRI antidepressants. Prescribed for Anxiety, Generalized Anxiety Disorder, Major Depressive... View more

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 1985 reviews

View all 386 reviews

Drug Class

Selective serotonin reuptake inhibitors

Miscellaneous antidepressants

Side Effects

Common side effects include: diarrhea, drowsiness, ejaculatory disorder, headache, insomnia, nausea, and delayed ejaculation.

See the full Lexapro side effects document.

Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, and xerostomia.

See the full Wellbutrin XL side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 tablet
Dosage	10 mg
Per Unit^*	$8.27
Cost^*	$248.16

View all Lexapro prices and generic prices

Quantity	30 tablet, extended release
Dosage	150 mg/24 hours
Per Unit^*	$55.51
Cost^*	$1,665.16

View all Wellbutrin XL prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral solution
Oral tablet

Oral tablet, extended release

Brand Names

N/A

Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

32 hours

30 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 649 drugs are known to interact with Lexapro:

248 major drug interactions (885 brand and generic names)
356 moderate drug interactions (1613 brand and generic names)
45 minor drug interactions (147 brand and generic names)

A total of 423 drugs are known to interact with Wellbutrin XL:

212 major drug interactions (924 brand and generic names)
206 moderate drug interactions (862 brand and generic names)
5 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol can increase the nervous system side effects of escitalopram such as dizziness, drowsiness... View more

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

Disease Interactions

First Approval Date

August 14, 2002

August 28, 2003

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Prescribing Information

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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